Allopregnanolone concentration and mood -: a bimodal association in postmenopausal women treated with oral progesterone
Allopregnanolone concentration and mood -: a bimodal association in postmenopausal women treated with oral progesterone
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DOI：
10.1007/s00213-006-0417-0
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发表时间：
2006-08-01
影响因子：
3.4
通讯作者：
Backstrom, Torbjorn
中科院分区：
文献类型：
--
作者：
Andreen, Lotta;Sundstrom-Poromaa, Inger;Backstrom, Torbjorn
基本原理：Allopregnanolone对绝经后妇女情绪的影响迄今尚不清楚。目的：Allopregnanolone是一种具有矛盾作用的神经活性类固醇。麻醉，镇静，抗焦虑，以及侵略性和致焦虑特性已被报道。本研究的目的是比较妇女接受不同的血清allopregnanolone浓度在孕酮treatment.Materials和方法：一个随机的，安慰剂对照的，双盲，交叉研究的绝经后妇女（n=43）在四个治疗周期，每天2毫克雌二醇治疗的严重程度。口服微粒化孕酮30，60和200毫克/天，安慰剂依次加入到每个周期。参与者使用经验证的评级量表保持每日症状评级。在每个治疗cycle.Results：孕酮治疗期间，妇女有显着较高的负面情绪评分时，allopregnanolone血清浓度在1.5-2 nmol/L的范围内，相比较低和较高的浓度。此外，与每天使用30 mg孕酮的仅雌二醇治疗期相比，在孕酮治疗期间，女性的负面情绪显着增加。另一方面，治疗与更高剂量的孕酮没有影响消极mood.Conclusions：情绪的影响，在孕酮治疗过程中似乎与alopregnanolone浓度，和alopregnanolone和不良情绪之间的双峰关联是显而易见的。
Rationale: Allopregnanolone effects on mood in postmenopausal women are unclear thus far.Objectives: Allopregnanolone is a neuroactive steroid with contradictory effects. Anaesthetic, sedative, and anxiolytic as well as aggressive and anxiogenic properties have been reported. The aim of this study is to compare severity of negative mood between women receiving different serum allopregnanolone concentrations during progesterone treatment.Materials and Methods: A randomized, placebo-controlled, double-blind, crossover study of postmenopausal women (n=43) treated with 2 mg estradiol daily during four treatment cycles. Oral micronized progesterone at 30, 60, and 200 mg/day, and placebo were added sequentially to each cycle. Participants kept daily symptom ratings using a validated rating scale. Blood samples for progesterone and allopregnanolone analyses were collected during each treatment cycle.Results: During progesterone treatment, women had significantly higher negative mood scores when allopregnanolone serum concentration was in the range of 1.5-2 nmol/l compared to lower and higher concentrations. In addition, women displayed a significant increase in negative mood during the progesterone treatment period, compared to the estradiol-only period when 30 mg progesterone daily was used. On the other hand, treatment with higher doses of progesterone had no influence on negative mood.Conclusions: Mood effects during progesterone treatment seem to be related to allopregnanolone concentration, and a bimodal association between allopregnanolone and adverse mood is evident.