Clinical efficacy analysis of Ahmed glaucoma valve implantation in neovascular glaucoma and influencing factors: A STROBE-compliant article.
Clinical efficacy analysis of Ahmed glaucoma valve implantation in neovascular glaucoma and influencing factors: A STROBE-compliant article.
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Ahmed青光眼阀植入术治疗新生血管性青光眼的临床疗效及影响因素分析：一篇符合STROBE标准的文章
DOI：
10.1097/md.0000000000008350
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发表时间：
2017-10
期刊：
影响因子：
1.6
通讯作者：
Xia X
中科院分区：
文献类型：
--
作者：
He Y;Tian Y;Song W;Su T;Jiang H;Xia X
本研究旨在评价Ahmed青光眼阀（AGV）植入术治疗新生血管性青光眼（NVG）的疗效并分析影响手术成功率的因素。回顾性分析2014年1月至2016年12月在中南大学湘雅医院接受AGV植入术的40例NVG患者的40只眼，观察术前及术后眼压（IOP）、视力、手术成功率、药物及并发症情况。手术成功的标准定义为 IOP ≤ 21 且 > 6 mm Hg，无论是否使用其他药物。 Kaplan-Meier 生存曲线和多变量 cox 回归分析用于检查手术结果的成功率和风险因素。平均随访时间为 8.88±3.12 个月（范围：3-17）。术后每次访视眼压均下降，且具有统计学意义（P < .001）。术前平均用药3.55±0.86种，术后平均用药0.64±0.90种，差异有统计学意义（P＜ .05）。术后3、6、12个月的手术完全成功率分别为85%、75%、65%。同时，术后3、6、12个月的合格成功率分别为85%、80%、77.5%。多因素cox回归分析显示，年龄（风险比：3.717、7.246；95%置信区间：1.149-12.048、1.349-38.461；P = .028、.021）是所有NVG患者完全成功率和合格成功率的影响因素。性别、既往手术史、原发病、术前眼压差异不显着。 AGV植入术是治疗NVG的有效且安全的手术方法。年龄是影响手术成功率的重要因素。
This study aimed to evaluate the efficacy of Ahmed glaucoma valve (AGV) implantation in treating neovascular glaucoma (NVG) and to analyze the factors influencing the surgical success rate. This is a retrospective review of 40 eyes of 40 NVG patients who underwent AGV implantation at Xiangya Hospital of Central South University, China, between January 2014 and December 2016. Pre- and postoperative intraocular pressure (IOP), visual acuity, surgical success rate, medications, and complications were observed. Surgical success criteria were defined as IOP ≤21 and >6 mm Hg with or without additional medications. Kaplan–Meier survival curves and Multivariate cox regression analysis were used to examine success rates and risk factors for surgical outcomes. The mean follow-up period was 8.88 ± 3.12 months (range: 3–17). IOP declined at each visit postoperatively and it was statistically significant (P < .001). An average of 3.55 ± 0.86 drugs was applied preoperatively, while an average of 0.64 ± 0.90 drugs was used postoperatively, with the difference being of statistical significance (P < .05). The complete surgical success rate of 3, 6, and 12 months after the operation was 85%, 75%, and 65%, respectively. Meanwhile, the qualified success rate of 3, 6, and 12 months after the operation was 85%, 80%, and 77.5%, respectively. The multivariate cox regression analysis showed that age (hazard ratio: 3.717, 7.246; 95% confidence interval: 1.149–12.048, 1.349–38.461; P = .028, .021) was influencing factors for complete success rate and qualified success rate among all NVG patients. Gender, previous operation history, primary disease, and preoperative IOP were found to be not significant. AGV implantation is an effective and safe surgical method to treat NVG. Age is an important factor influencing the surgical success rate.