Oxidative Damage, Platelet Activation, and Inflammation to Predict Mobility Disability and Mortality in Older Persons: Results From the Health Aging and Body Composition Study
Oxidative Damage, Platelet Activation, and Inflammation to Predict Mobility Disability and Mortality in Older Persons: Results From the Health Aging and Body Composition Study
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DOI：
10.1093/gerona/glr246
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发表时间：
2012-06-01
影响因子：
5.1
通讯作者：
Pahor, Marco
中科院分区：
文献类型：
--
作者：
Cesari, Matteo;Kritchevsky, Stephen B.;Pahor, Marco
炎症、氧化损伤和血小板活化是驱动失能过程的假设生物学机制。本研究的目的是评估代表这些机制的生物标志物是否能预测老年人主要的不良健康事件。数据来自2234名社区居住的非残疾老年人，他们参加了健康老龄化和身体成分研究。脂质过氧化的生物标志物（如尿中8-异前列腺素F-2 α水平）、血小板活化（如尿中11-脱氢血栓素B-2水平）和炎症（血清白介素6浓度）被视为感兴趣的独立变量，并在Cox比例风险模型中作为（严重）行动障碍和总死亡率的预测因子进行了测试。样本（女性48.0%，白人64.3%）的平均年龄为74.6岁（SD 2.9）。在随访期间（中位11.4年），分别发生792例（35.5%）、269例（12.0%）和942例（42.2%）行动不便、严重行动不便和死亡事件。只有白细胞介素-6与所有研究结果的开始有显著的独立关联。较高水平的尿8-异前列腺素F-2 α和11-脱氢血栓素B-2独立预测死亡风险增加（风险比分别为1.10,95%置信区间1.03-1.19和1.14,95%置信区间1.06-1.23）。性别、种族、心血管疾病、糖尿病和抗血小板药物在研究关系中未发现显著的相互作用。炎症标志物白细胞介素-6已被证实是负面健康相关事件发生的可靠预测因子。尿中8-异前列腺素F-2 α和11-脱氢血栓素B-2水平较高的参与者死亡风险较高。
Inflammation, oxidative damage, and platelet activation are hypothesized biological mechanisms driving the disablement process. The aim of the present study is to assess whether biomarkers representing these mechanisms predicted major adverse health-related events in older persons.Data are from 2,234 community-dwelling nondisabled older persons enrolled in the Health Aging and Body Composition study. Biomarkers of lipid peroxidation (ie, urinary levels of 8-iso-prostaglandin F-2 alpha), platelet activation (ie, urinary levels of 11-dehydro-thromboxane B-2), and inflammation (serum concentrations of interleukin-6) were considered as independent variables of interest and tested in Cox proportional hazard models as predictors of (severe) mobility disability and overall mortality.The sample's (women 48.0%, whites 64.3%) mean age was 74.6 (SD 2.9) years. During the follow-up (median 11.4 years), 792 (35.5%), 269 (12.0%), and 942 (42.2%) events of mobility disability, severe mobility disability, and mortality occurred, respectively. Only interleukin-6 showed significant independent associations with the onset of all the study outcomes. Higher levels of urinary 8-iso-prostaglandin F-2 alpha and 11-dehydro-thromboxane B-2 independently predicted increased risk of death (hazard ratio 1.10, 95% confidence interval 1.03-1.19 and hazard ratio 1.14, 95% confidence interval 1.06-1.23, respectively). No significant interactions of gender, race, cardiovascular disease, diabetes, and antiplatelet drugs were detected on the studied relationships.The inflammatory marker interleukin-6 is confirmed to be a robust predictor for the onset of negative health-related events. Participants with higher urinary levels of 8-iso-prostaglandin F-2 alpha and 11-dehydro-thromboxane B-2 presented a higher mortality risk.