Estimating hepatitis C infection acquired in England, 1986-2000
Estimating hepatitis C infection acquired in England, 1986-2000
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DOI：
10.1017/s0950268809002143
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发表时间：
2009-09-01
影响因子：
4.2
通讯作者：
Ramsay, M. E.
中科院分区：
文献类型：
--
作者：
Balogun, M. A.;Vyse, A. J.;Ramsay, M. E.
丙型肝炎是一个全球性的健康问题，在英国，血清阳性率研究主要集中在特定的高危人群。本研究的目的是确定在英国丙型肝炎病毒抗体流行的变化，使用1986年和2000年之间收集的剩余标本，反映了一般人群。一项横断面研究设计，使用方便收集的血清标本，从成年患者提交给实验室在1986年，1991年，1996年和2000年，共19个实验室在英格兰各地进行了调查。主要结果是确定1986年至2000年期间抗HCV流行率和平均发病率以及与感染相关的因素。多因素分析结果显示，不同性别、不同出生队列和不同健康地区的患病率差异有统计学意义（P <0.001）。平均0.72%（95%CI 0-1.65%）的1950年至1970年间出生的HCV易感人群估计在1986年至2000年间感染。结果表明，普通人群HCV感染率较低，且与出生时间、性别、健康地区有关。有证据表明，在1986-2000年期间，1950年至1970年出生的人群中HCV感染的发病率较低，在人口水平上，相当于相当大的感染负担（类似于106000人）。针对注射毒品使用者的持续监测和预防对于控制英国的丙型肝炎至关重要。
Hepatitis C is a global health problem and in the UK seroprevalence studies have mainly concentrated on specific high-risk groups. The aim Of this Study was to determine changes in the prevalence of antibody to hepatitis C virus in England using residual specimens collected between 1986 and 2000 reflecting the general population. A cross-sectional study design using a convenience collection of serum specimens from adult patients submitted to laboratories in the years 1986, 1991, 1996 and 2000 from a total of 19 laboratories around England were investigated. The main outcome was to determine anti-HCV prevalence and the average incidence occurring between 1986 and 2000 and factors associated with infection. Multivariable analysis of results from all years showed there was a significant difference in prevalence between males and females (P < 0.001), birth cohort (P < 0.001) and by health region (P < 0.001). An average of 0.72% (95% CI 0-1.65%) of those susceptible to HCV born between 1950 and 1970 were estimated to have acquired the infection between 1986 and 2000. Analysis of this convenience serum collection Suggests that HCV prevalence is low in the general Population, and is associated with period of birth, gender and health region. There was evidence to support a low incidence of HCV infection in those born between 1950 and 1970 over the period 1986-2000 which, at the population level, equated to a Substantial burden of infection (similar to 106000 persons). Continued surveillance and prevention targeted at injecting drug users are essential for the control of hepatitis C in the UK.