Patterning polyacrylamide hydrogels by soft lithography
Patterning polyacrylamide hydrogels by soft lithography
复制标题
DOI：
10.1088/0957-4484/16/5/006
复制
发表时间：
2005-05-01
期刊：
影响因子：
3.5
通讯作者：
Cingolani, R
中科院分区：
文献类型：
--
作者：
Di Benedetto, F;Biasco, A;Cingolani, R
由于水凝胶的化学柔韧性和广泛的应用，生物相容性凝胶结构的直接图图化当然值得充分探索。本文介绍了一种用软光刻技术制备聚丙烯酰胺水凝胶图案的方法。为了将微观结构直接转移到聚丙烯酰胺中，采用了室温模塑，以平行的方式达到2 μ m的分辨率。在印迹过程中，凝胶在液体状态下流动成印章的形状，由自发毛细管作用和压力诱导传输的组合驱动，不使用任何光子束，溶剂和化学表面处理。聚合后的系统，印章图案的负副本因此被冻结在目标材料表面。
Because of the chemical flexibility and broad range of applications of hydrogels, the direct patterning of biocompatible gel structures certainly deserves to be fully explored. This paper describes a method of creating hydrogel patterns of poly(acrylamide) by soft lithography. Room-temperature moulding is employed in order to directly transfer microstructures into poly(acrylamide), in a parallel manner up to a resolution of 2 mu m. During the imprinting process, the gel at the liquid state flows into the shape of the stamp, driven by a combination of spontaneous capillarity and pressure-induced transport, without using any photon-beam, solvent, and chemical surface treatment. After the polymerization of the system, a negative copy of the stamp pattern is therefore frozen on the target material surface.