Did I Do That? Abnormal Predictive Processes in Schizophrenia When Button Pressing to Deliver a Tone
Did I Do That? Abnormal Predictive Processes in Schizophrenia When Button Pressing to Deliver a Tone
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DOI：
10.1093/schbul/sbt072
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发表时间：
2014-07-01
影响因子：
6.6
通讯作者：
Mathalon, Daniel H.
中科院分区：
文献类型：
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作者：
Ford, Judith M.;Palzes, Vanessa A.;Mathalon, Daniel H.
运动动作之前是运动指令的传出副本，导致感觉皮质中预期感觉的必然放电。这些机制允许动物预测感觉，抑制对自身产生的感觉的反应，从而高效而经济地处理感觉。在说话过程中，精神分裂症患者的说话前活动较少，语音抑制较少，分别与传出复制功能障碍和必然放电功能障碍相一致。我们询问在说话中看到的模式是否会推广到按下按钮来听到音调，这是一种可以翻译给声音较少的动物的范例。在26名患者[23名精神分裂症患者，3名分裂情感性患者(SZ)]和22名健康对照(HC)中，通过比较N1与按钮按下传递的音调和N1与回放的音调来估计听觉事件相关电位N1分量的抑制。通过比较左右半球的神经活动来估计与按压传递音调之前的运动计划相关的偏侧化准备潜势(LRP)。分析N1抑制与LRP波幅的关系。LRP在前按键传递音调时，HC比SZ大，N1抑制也大。LRP波幅和N1抑制在两组中都是相关的，这表明更强的传出拷贝与更强的必然放电相关。SZ减少了N1抑制，反映了必然的放电行为，并在按钮按下之前减少了较小的LRPS来传递音调，反映了运动计划的传出副本。在发声过程中看到的影响很大程度上延伸到其他更容易翻译给实验室动物的运动动作。
Motor actions are preceded by an efference copy of the motor command, resulting in a corollary discharge of the expected sensation in sensory cortex. These mechanisms allow animals to predict sensations, suppress responses to self-generated sensations, and thereby process sensations efficiently and economically. During talking, patients with schizophrenia show less evidence of pretalking activity and less suppression of the speech sound, consistent with dysfunction of efference copy and corollary discharge, respectively. We asked if patterns seen in talking would generalize to pressing a button to hear a tone, a paradigm translatable to less vocal animals. In 26 patients [23 schizophrenia, 3 schizoaffective (SZ)] and 22 healthy controls (HC), suppression of the N1 component of the auditory event-related potential was estimated by comparing N1 to tones delivered by button presses and N1 to those tones played back. The lateralized readiness potential (LRP) associated with the motor plan preceding presses to deliver tones was estimated by comparing right and left hemispheres' neural activity. The relationship between N1 suppression and LRP amplitude was assessed. LRP preceding button presses to deliver tones was larger in HC than SZ, as was N1 suppression. LRP amplitude and N1 suppression were correlated in both groups, suggesting stronger efference copies are associated with stronger corollary discharges. SZ have reduced N1 suppression, reflecting corollary discharge action, and smaller LRPs preceding button presses to deliver tones, reflecting the efference copy of the motor plan. Effects seen during vocalization largely extend to other motor acts more translatable to lab animals.