Delayed luminance and chromatic contrast sensitivity in infants with spontaneously regressed retinopathy of prematurity.
Delayed luminance and chromatic contrast sensitivity in infants with spontaneously regressed retinopathy of prematurity.
复制标题
DOI：
10.1007/s10633-013-9395-9
复制
发表时间：
2013-08
影响因子：
1.4
通讯作者：
Dobkins, Karen R.
中科院分区：
文献类型：
--
作者：
Bosworth, Rain G.;Robbins, Shira L.;Granet, David B.;Dobkins, Karen R.
目前的研究评估了有自发性退行性早产儿视网膜病变(ROP，1-3期)病史的早产儿对比敏感度是否受到影响。具体地说，我们采用了亮度(明/暗)和色(红/绿)刺激，这两种刺激分别由大细胞(M)和小细胞(P)皮质下通路介导。对21例有ROP病史的早产儿和41例未发生ROP的对照早产儿进行对比敏感度(CS)测试，测试时间为8~47周(2~11个月)。在每一次实验中，婴儿都会看到彩色和亮度漂移的正弦网格，它们随机出现在监视器的左侧或右侧。刺激的对比度在不同的试验中有所不同，并根据中长锥体的均方根锥体对比度来定义。在产后8到25周，ROP婴儿的CS明显更差，而且亮度的损害有比彩色CS更严重的趋势。这种延迟在产后26到47周的年龄较大的人群中看不到。这些发现与M通路的早期成熟比P通路更容易受到生物学伤害的概念一致，就像ROP的情况一样。
The current study assessed whether contrast sensitivity is affected in preterm infants with a history of spontaneously regressed retinopathy of prematurity (ROP, Stages 1–3). Specifically, we employed luminance (light/dark) and chromatic (red/green) stimuli, which are mediated by the magnocellular (M) and parvocellular (P) subcortical pathways, respectively. Contrast sensitivity (CS) was measured using forced choice preferential looking testing in 21 infants with a history of ROP and 41 control preterm infants who were born prematurely but did not develop ROP, tested between 8 and 47 weeks (2–11 months) postterm age. Infants were presented with chromatic and luminance drifting sinusoidal gratings, which appeared randomly on the left or right side of the monitor on each trial. The contrast of the stimuli varied across trials and was defined in terms of root mean squared cone contrast for long- and medium-wavelength cones. Between 8 and 25 weeks postterm, ROP infants had significantly worse CS, and there was a trend for greater impairment for Luminance than Chromatic CS. This delay was not seen at older ages between 26 and 47 weeks postterm. These findings are consistent with the concept that early maturation of the M pathway is vulnerable to biological insult, as in the case of ROP, to a greater extent than is the P pathway.
登录
查看更多内容
影响因子：
1.8
作者：
Dobkins, KR;Anderson, CM;Kelly, J
通讯作者：
Kelly, J
影响因子：
1.9
作者：
FLORENCE, SL;CASAGRANDE, VA
通讯作者：
CASAGRANDE, VA
影响因子：
4.4
作者：
Barnaby, Amber M.;Hansen, Ronald M.;Fulton, Anne B.
通讯作者：
Fulton, Anne B.
影响因子：
1.8
作者：
Dobkins, KR;Anderson, CM;Lia, B
通讯作者：
Lia, B
影响因子：
1.8
作者：
DZMURA, M;LENNIE, P
通讯作者：
LENNIE, P