Effect of intrathecal administration of hemokinin-1 on the withdrawal response to noxious thermal stimulation of the rat hind paw
Effect of intrathecal administration of hemokinin-1 on the withdrawal response to noxious thermal stimulation of the rat hind paw
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DOI：
10.1016/j.neulet.2005.09.005
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发表时间：
2006-01-09
影响因子：
2.5
通讯作者：
Nishimori, T
中科院分区：
文献类型：
--
作者：
Endo, D;Ikeda, T;Nishimori, T
血激肽-1（HK-1）是一种新肽，属于速激肽家族成员。HK-1在中枢给药后具有类似于P物质（SP）的生物学效应，P物质是速激肽家族的代表。然而，HK-1在脊髓水平的生物学功能尚未得到很好的表征。因此，我们通过比较HK-1和SP的作用来研究HK-1鞘内给药的作用。10（-3）M的HK-1和SP鞘内给药引起疼痛相关行为，如抓挠。用P物质受体拮抗剂预处理可抑制HK-1的抓挠作用。此外，鞘内注射Sp（10（-8）~ 10（-6）M）后20- 30 min，可明显缩短热伤害性刺激引起的缩足反应的潜伏期，而HK-1对缩足反应无明显影响。这些结果表明，可能存在与HK-1相关的受体。(C)2005爱思唯尔爱尔兰有限公司保留所有权利。
Hemokinin-1 (HK-1) is a new peptide described as a member of the tachykinin family. HK-1 has biological effects similar to substance P (SP), a representative of the tachykinin family, following central administration. However, the biological function of HK-1 at the spinal level has not been well characterized. Thus, we investigated the effect of intrathecal administration of HK-1 by comparing it with that of SP. Intrathecal administration of HK-1 as well as SP at 10(-3) M caused pain-related behavior such as scratching. The scratching by HK-1 administration was inhibited by pretreatment with an antagonist of substance P receptor. In addition, Sp (10(-8)-10(-6) M) decreased the latency of the withdrawal response of the hind paw to noxious thermal stimulation 20-30min after intrathecal administration, whereas administration of HK-1 had little effect on this response. These results suggest that there may exist a proper receptor related to HK-1. (C) 2005 Elsevier Ireland Ltd. All rights reserved.