A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population
A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population
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DOI：
10.1016/j.psychres.2011.09.001
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发表时间：
2012-04-30
影响因子：
11.3
通讯作者：
Someya, Toshiyuki
中科院分区：
文献类型：
--
作者：
Egawa, Jun;Watanabe, Yuichiro;Someya, Toshiyuki
我们在日本人群中使用19个标记进行了色氨酸羟化酶2基因与自闭症谱系障碍之间的详细关联分析，包括标记单核苷酸多态性和通过外显子重测序鉴定的新型错义变异p.R225Q。然而，我们未能获得相关的支持性证据。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
We conducted a detailed association analysis between the tryptophan hydroxylase 2 gene and autism spectrum disorders in a Japanese population using 19 markers, including tagging single nucleotide polymorphisms and a novel missense variation, p.R225Q identified through exon resequencing. However, we failed to obtain supportive evidence for an association. (C) 2011 Elsevier Ireland Ltd. All rights reserved.