Prior statin therapy is associated with a decreased rate of severe sepsis
Prior statin therapy is associated with a decreased rate of severe sepsis
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DOI：
10.1161/01.cir.0000138932.17956.f1
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发表时间：
2004-08-17
期刊：
影响因子：
37.8
通讯作者：
Danon, A
中科院分区：
文献类型：
--
作者：
Almog, Y;Shefer, A;Danon, A
背景-他汀类药物具有抗炎特性，不依赖于其降脂能力。我们假设在急性细菌感染发作前使用他汀类药物治疗可能对严重脓毒症有保护作用。本研究的目的是确定是否与他汀类药物治疗的患者发展严重脓毒症的频率较低。方法和结果，在这个前瞻性的观察性队列研究，连续入院的患者与假定或记录的急性细菌感染。主要结果是严重脓毒症和重症监护室（ICU）入院率。在入组的361例患者中，82例（22.7%）在入院前接受了他汀类药物治疗。两组患者入院时病情严重程度相似。无他汀组19%的患者发生严重脓毒症，而他汀组仅为2.4%（P
Background-Statins have anti-inflammatory properties that are independent of their lipid-lowering abilities. We hypothesized that statin therapy before the onset of an acute bacterial infection may have a protective effect against severe sepsis. The aim of this study was to determine whether patients treated with statins develop severe sepsis less frequently.Methods and Results-In this prospective observational cohort study, consecutive patients admitted with presumed or documented acute bacterial infection were enrolled. The primary outcomes were the rate of severe sepsis and intensive care unit (ICU) admission. Of the 361 patients enrolled, 82 (22.7%) were treated with statins before their admission. Both groups had a similar severity of illness on admission. Severe sepsis developed in 19% of patients in the no-statin group and in only 2.4% of the statin group (P