The difficult quest for data on "vanishing" vaccine-preventable infections in Europe: the case of measles in Flanders (Belgium)
The difficult quest for data on "vanishing" vaccine-preventable infections in Europe: the case of measles in Flanders (Belgium)
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DOI：
10.1016/s0264-410x(02)00335-3
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发表时间：
2002-10-04
期刊：
影响因子：
5.5
通讯作者：
Meheus, A
中科院分区：
文献类型：
--
作者：
Beutels, P;Van Damme, P;Meheus, A
我们的目的是描述疫苗接种对比利时佛兰德斯麻疹感染流行病学的影响，根据这些证据记录可能的疫苗接种覆盖率，将这些流行病学数据与数学模型产生的数据进行比较，并估计麻疹发病的成本。与以前的分析不同，我们包括了脑炎和亚急性硬化性全脑炎(SSPE)后遗症的长期护理费用。我们估计，在0-4、5-9、10-14、15-19岁和大于或等于20年的年龄组中，每个麻疹病例的直接医疗费用分别为227欧元、212欧元、210欧元、200欧元和194欧元。不包括长期护理，根据年龄段的不同，这些估计值会降低22%-51%。通过包括间接时间成本，我们得出每个麻疹病例的总成本分别为320欧元、305欧元、210欧元、200欧元和625欧元。除了将来更严格地登记疫苗接种覆盖面外，似乎有必要进行血清阳性率研究，以证明对麻疹的特定年龄免疫力。通过利用这些信息，可以调整目前的疫苗接种战略，以防止未来爆发，并帮助以有效的方式从欧洲消除麻疹。我们自始至终都注意到，许多数据源都是有缺陷的。为了提高今后类似研究的可靠性，需要有更好和更容易获得的数据库。(C)2002爱思唯尔科学有限公司。保留所有权利。
We aimed to describe the impact of vaccination on the epidemiology of measles infection in Flanders (Belgium), to document probable vaccination coverage based on this evidence, compare these epidemiological data with those generated by a mathematical model and estimate the costs of morbidity from measles. In contrast to previous analyses, we included the costs of long-term care for sequelae due to encephalitis and subacute sclerosing panencephalitis (SSPE). We estimated the direct health care costs per average measles case at EURO 227, 212, 210, 200 and 194 for the age groups of 0-4, 5-9, 10-14, 15-19 and greater than or equal to20 years, respectively. Excluding long-term care lowers these estimates by 22-51%, depending on the age group. By including indirect time costs, we arrive at total costs per measles case of euro 320, 305, 210, 200 and 625, respectively. In addition to registering vaccination coverage more rigorously in the future, it seems necessary to undertake seroprevalence studies to document the age-specific immunity to measles. By using such information, current vaccination strategies can be adapted to prevent future outbreaks and to help eliminate measles from Europe in an efficient way. We noted throughout that many of the data sources are flawed. Better and accessible data bases are required to improve the reliability of similar studies in the future. (C) 2002 Elsevier Science Ltd. All rights reserved.