Plasmodium falciparum AMA1 binds a rhoptry neck protein homologous to TgRON4, a component of the moving junction in Toxoplasma gondii
Plasmodium falciparum AMA1 binds a rhoptry neck protein homologous to TgRON4, a component of the moving junction in Toxoplasma gondii
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DOI：
10.1128/ec.00040-06
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发表时间：
2006-07-01
期刊：
影响因子：
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通讯作者：
Boothroyd, John C.
中科院分区：
文献类型：
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作者：
Alexander, David L.;Arastu-Kapur, Shirin;Boothroyd, John C.
恶性疟原虫顶端膜抗原I（PFAMA1）与Tgron4的疟原虫同源物共免疫沉淀，Tgron4是Toxoplasma gondii的分泌的Rhoptry颈部蛋白，在入侵期间与TGAMA1相关联，该弓形虫的分泌颈部蛋白。 PFRON4也起源于Rhoptry脖子，这表明这种不寻常的Micronemes和Rhoptries的合作是Apicomplexa的保守特征。
Plasmodium falciparum apical membrane antigen I (PfAMA1) coimmunoprecipitates with the Plasmodium homologue of TgRON4, a secreted rhoptry neck protein of Toxoplasma gondii that migrates at the moving junction in association with TgAMA1 during invasion. PfRON4 also originates in the rhoptry necks, suggesting that this unusual collaboration of micronemes and rhoptries is a conserved feature of Apicomplexa.