Endometriosis and ovarian cancer: links, risks, and challenges faced.
Endometriosis and ovarian cancer: links, risks, and challenges faced.
复制标题
DOI：
10.2147/ijwh.s66824
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Lyttle BM
中科院分区：
文献类型：
--
作者：
Pavone ME;Lyttle BM
子宫内膜异位症是一种良性妇科疾病，具有特定的组织学、分子和临床表现。它影响 5%–10% 的绝经前女性，是不孕的原因，并且被认为是某些类型卵巢癌的先兆。技术的进步，主要是全基因组测序的能力，使人们发现了新的突变，并更好地了解了先前发现的与子宫内膜异位症相关卵巢癌 (EAOC) 相关的基因和通路的功能，包括 PTEN、CTNNB1（β-连环蛋白）、KRAS、微卫星不稳定性、ARID1A 以及炎症在 EAOC 发展中的独特作用。临床上，EAOC与诊断时年龄较小、肿瘤分期和级别较低有关，并且与其他卵巢癌相比，更容易发生在绝经前女性身上。预防 EAOC 筛查策略的转变导致国家和国际管理机构对临床实践提出了新的建议。在本文中，我们回顾了子宫内膜异位症和卵巢癌的常见组织学和分子特征、与 EAOC 相关的风险、临床挑战，并为提供者提供建议。
Endometriosis is a benign gynecological condition characterized by specific histological, molecular, and clinical findings. It affects 5%–10% of premenopausal women, is a cause of infertility, and has been implicated as a precursor for certain types of ovarian cancer. Advances in technology, primarily the ability for whole genome sequencing, have led to the discovery of new mutations and a better understanding of the function of previously identified genes and pathways associated with endometriosis associated ovarian cancers (EAOCs) that include PTEN, CTNNB1 (β-catenin), KRAS, microsatellite instability, ARID1A, and the unique role of inflammation in the development of EAOC. Clinically, EAOCs are associated with a younger age at diagnosis, lower stage and grade of tumor, and are more likely to occur in premenopausal women when compared with other ovarian cancers. A shift from screening strategies adopted to prevent EAOCs has resulted in new recommendations for clinical practice by national and international governing bodies. In this paper, we review the common histologic and molecular characteristics of endometriosis and ovarian cancer, risks associated with EAOCs, clinical challenges and give recommendations for providers.