DENDRITIC PLASTICITY IN MOUSE BARREL CORTEX FOLLOWING POSTNATAL VIBRISSA FOLLICLE DAMAGE
DENDRITIC PLASTICITY IN MOUSE BARREL CORTEX FOLLOWING POSTNATAL VIBRISSA FOLLICLE DAMAGE
复制标题
DOI：
10.1002/cne.901960302
复制
发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
WOOLSEY, TA
中科院分区：
文献类型：
--
作者：
HARRIS, RM;WOOLSEY, TA
新生儿损伤的一排mystyrus触须在小鼠引起cytoarchitectonic改变对侧Sm[体感]我桶皮质。适当排筒的区域发展为较小的均质区，而相邻排中的筒被扩展。为了研究这种现象对单个神经元形态的影响，通过Golgi-Cox方法处理在出生后第1-5天烧灼Row-C触须（中间行）的成年小鼠。用计算机辅助显微镜测量了对照半球的Row-C区、Row-C桶的第IV层中的所有神经元以及相邻放大的Row-B桶中的一些神经元。它们相对于细胞结构边界的位置由尼氏复染确定。提供了来自239个细胞的数据。对于每个细胞，获得树突长度和分支的测量。还测量了树枝状树相对于桶侧的取向。树突长度和分支的测量结果在对照组和实验组动物之间，或者在不同日期受损的动物之间没有显示出任何差异。定向的测量结果确实显示出与损伤时的年龄相关的变化。在出生后第3天或更早受损的动物中，观察到C排区的许多细胞具有朝向相邻B排或D排的树突。在行B和D的扩展部分中的假定行C细胞强烈地朝向那些行中的桶。树突的长度和分支可能是固有的，但树突树的方向似乎受到强烈的影响，从丘脑的外部传入输入的模式。在胡须受损的动物中，行C神经元树突树朝向行B和D中的功能性丘脑皮质输入的方向对所产生的细胞结构变化有很大贡献。被认为是正常的发育过程和它们之间的关系的皮质功能研究的inplications。
Neonatal damage to a row of mystacial vibrissae in the mouse causes cytoarchitectonic alterations in the contralateral Sm[somatosensory]I barrel cortex. The region for the appropriate row of barrels develops as a smaller homogeneous zone, while barrels in adjacent rows are expanded. To investigate the effects of this phenomenon on the morphology of individual neurons, adult mice in which Row-C vibrissae (the middle row) had been cauterized on days 1-5 following birth were processed by the Golgi-Cox method. All neurons in layer IV of the Row-C zones, of the Row-C barrels of a control hemisphere, and some neurons in the adjacent enlarged Row-B barrels were measured with a computer-assisted microscope. Their location with respect to cytoarchitectonic boundaries was determined from a Nissl counterstain. Data from 239 cells are presented. For each cell, measures of dendritic length and branching were obtained. The orientation of the dendritic trees with respect to the barrel sides was also measured. The measures of dendritic lengths and branching did not show any differences between control and experimental animals, or between animals damaged on different days. Measures of orientation did show changes related to the age at the time of damage. In animals damaged on postnatal day-3 or earlier, many cells in the Row-C zone were observed with dendrites orienting toward the adjacent Rows-B or -D. Putative Row-C cells in the expanded parts of Rows-B and -D were strongly oriented toward barrels in those rows. Dendritic length and branching may be determined intrinsically, but the orientation of the dendritic trees appears to be strongly influenced by the pattern of extrinsic afferent inputs from the thalamus. In the whisker-damaged animals, the orientation of the Row-C neuron dendritic trees toward the functional thalamocortical inputs in Rows-B and -D contributes strongly to the resultant cytoarchitectonic changes. The inplications for normal developmental processes and their relationship to functional studies of the cortex are considered.