Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts
Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts
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DOI：
10.1186/s12906-018-2322-6
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发表时间：
2018-09-17
影响因子：
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通讯作者：
Ramirez de Molina, Ana
中科院分区：
文献类型：
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作者：
Mouhid, Lamia;Gomez de Cedron, Marta;Ramirez de Molina, Ana
背景：胰腺癌是最具侵袭性和致命性的癌症之一。虽然已经提出了几种药物用于治疗，但它仍然具有耐药性，需要新的替代品。在这种情况下，植物及其衍生物构成了可能有效抑制肿瘤细胞进展的生物活性成分的相关来源。在本研究中，我们分析了不同菊科植物的潜在抗癌作用（千里光和金盏花）和唇形科不同绿色技术获得的香蜂草和牛至植物提取物（超临界CO2萃取-SFE-和超声波辅助萃取-UAE）来鉴定针对人类胰腺癌细胞的有效植物提取物，这可能构成新治疗方法的基础。通过诱导细胞毒性和抑制细胞转化，菊科提取物显示出比唇形科提取物更好的抗肿瘤效果，超临界萃取物的抑菌效果优于超临界萃取物。此外，SFE来源于千叶千里光和金盏菊的植物提取物显示出与化疗剂5-氟尿嘧啶的协同作用。这些结果显示了来源于西洋蓍和金盏花的SFE提取物如何抑制胰腺癌细胞生长，并可建议进行全面研究，以确定参与其生物活性的分子机制，最终目的是提出它们作为胰腺癌的潜在佐剂疗法
Background: Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been proposed for its treatment, it remains resistant and new alternatives are needed. In this context, plants and their derivatives constitute a relevant source of bioactive components which might efficiently inhibit tumor cell progression.Methods: In this study, we have analyzed the potential anti-carcinogenic effect of different Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts obtained by different green technologies (Supercritical CO2 Extraction -SFE- and Ultrasonic Assisted Extraction -UAE) to identify efficient plant extracts against human pancreatic cancer cells that could constitute the basis of novel treatment approaches.Results: Asteraceae extracts showed better results as antitumoral agents than Lamiaceae by inducing cytotoxicity and inhibiting cell transformation, and SFE extracts were most efficient than UAE extracts. In addition, SFE derived plant extracts from Achillea millefolium and Calendula officinalis displayed synergism with the chemotherapeutic 5-Fluororacil.Conclusion: These results show how Yarrow and Marigold SFE-derived extracts can inhibit pancreatic cancer cell growth, and could be proposed for a comprehensive study to determine the molecular mechanisms involved in their bioactivity with the final aim to propose them as potential adjuvants in pancreatic cancer therapy.