Drug resistance patterns among tuberculosis patients in Rome, 1990-1992
Drug resistance patterns among tuberculosis patients in Rome, 1990-1992
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DOI：
10.3109/00365549609037945
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发表时间：
1996-01-01
影响因子：
--
通讯作者：
Ippolito, G
中科院分区：
文献类型：
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作者：
Girardi, E;Antonucci, G;Ippolito, G
在1990-1992年期间，对意大利罗马407名结核病住院患者进行了结核分枝杆菌耐药性流行率和危险因素的评估。106株（26%）检出1种及以上药物耐药。耐药最多的是链霉素（18.4%），其次是异烟肼（10.3%）和利福平（7.9%）。23株（5.7%）对异烟肼和利福平均耐药。复发患者对至少一种药物的耐药以及对异烟肼和利福平的耐药更为常见（40.7%对22.1%,p < 0.001； 22.1%对1.2%,p < 0.001）。性别、原籍国和艾滋病毒感染与耐药流行率无显著相关性。在复发病例中，对至少一种药物的耐药性以及对异烟肼和利福平的耐药性在1969年以后有过结核病发作的受试者中较高。在所研究的人群中，耐药结核病的患病率很高，尽管该地区最初感染耐多药结核分枝杆菌菌株的风险似乎很低。这项研究表明，有必要加强对我国结核病耐药性的监测，并实施旨在确保结核病患者得到充分和彻底治疗的干预措施。
Prevalence of, and risk factors for, drug-resistance of Mycobacterium tuberculosis were assessed among 407 hospitalized patients with tuberculosis in Rome, Italy, during the period 1990-1992. Resistance to I or more drugs was detected in 106 isolates (26%). Resistance to streptomycin was the most common (18.4%), followed by isoniazid (10.3%) and rifampin (7.9%). 23 isolates (5.7%) were resistant to both isoniazid and rifampin. Resistance to at least I drug and resistance to both isoniazid and rifampin were significantly more common among recurrent cases (40.7% vs. 22.1%, p < 0.001; and 22.1% vs. 1.2%, p < 0.001). Sex, country of origin and HIV infection were not significantly associated with prevalence of drug resistance. Among recurrent cases, prevalence of resistance to at least I drug and of resistance to both isoniazid and rifampin, was higher in subjects who had had a previous episode of tuberculosis later than 1969. In the population studied the prevalence of drug-resistant tuberculosis was high, although the risk of initially becoming infected with a multidrug-resistant strain of M. tuberculosis in this area appears to be low. This study suggests the need for enhanced surveillance of drug-resistance of tuberculosis in our country and for implementation of intervention aimed to ensure adequate and complete therapy for patients with tuberculosis.