Breast carcinoma in men - A population-based study
Breast carcinoma in men - A population-based study
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DOI：
10.1002/cncr.20312
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发表时间：
2004-07-01
期刊：
影响因子：
6.2
通讯作者：
Hortobagyi, GN
中科院分区：
文献类型：
--
作者：
Giordano, SH;Cohen, DS;Hortobagyi, GN
背景男性乳腺癌是一种罕见的疾病，以前的大多数研究都是单机构系列研究，受样本量极小的限制。本研究的目的是填补男性乳腺癌的发病率、表现特征、预后因素和生存率方面的知识空白，并确定男性和女性乳腺癌的差异。数据来自国家癌症研究所监测，流行病学和最终结果1973-1998数据库。计算经统计学校正的发病率。比较了男性和女性患者的特征和呈现的肿瘤。进行单变量和多变量分析，以确定每个变量对总生存期的影响。按疾病分期比较男性和女性的生存率。研究期间，男性乳腺癌的发病率从每10万人0.86例显著增加到1.08例（P < 0.001）。男性诊断时的中位年龄较高（P < 0.001），更可能有淋巴结受累（P < 0.001），诊断时更晚期（P < 0.001），肿瘤雌激素受体（ER）（P < 0.001）和孕激素受体（PR）（P < 0.001）阳性。在多变量分析中，较大的肿瘤大小和淋巴结受累与生存期缩短相关。肿瘤分级和ER/PR状态似乎并不独立影响生存率。男性和女性疾病分期的相对生存率相似。虽然它仍然是一种罕见的疾病，但男性乳腺癌的发病率正在上升。男性乳腺癌与女性乳腺癌在流行病学和生物学上有一些差异。(C)2004年美国癌症协会。
BACKGROUND. Male breast carcinoma is an uncommon disease, and most previous studies have been single-institution series that were limited by extremely small sample sizes. The goals of the current study were to fill in the major gaps in knowledge regarding the incidence, presenting characteristics, prognostic factors, and survival rates of male breast carcinoma and to determine how breast carcinoma differs between men and women.METHODS. Data from the National Cancer Institute Surveillance, Epidemiology, and End Results 1973-1998 database were used. Age-adjusted incidence rates were calculated. Characteristics of the patients and presenting tumors were compared between men and women. Univariate and multivariate analyses were performed to determine the effect of each variable on overall survival. Survival rates by disease stage were compared for men and women.RESULTS. Over the years of the study, the incidence of male breast carcinoma increased significantly from 0.86 to 1.08 per 100,000 population (P < 0.001). Men had a higher median age at diagnosis (P < 0.001) and were more likely to have lymph node involvement (P < 0.001), a more advanced stage at diagnosis (P < 0.001), and tumors that were positive for estrogen receptor (ER) (P < 0.001) and progesterone receptor (PR) (P < 0.001). In multivariate analysis, larger tumor size and lymph node involvement were associated with shortened survival. Tumor grade and ER/PR status did not appear to independently influence survival. Relative survival rates by stage of disease for men and women were similar.CONCLUSIONS. Although it remains a rare disease, the incidence of male breast carcinoma is increasing. Breast carcinoma in men has some epidemiologic and biologic differences from breast carcinoma in women. (C) 2004 American Cancer Society.