Assessment of molecular events in squamous and non-squamous cell lung carcinoma
Assessment of molecular events in squamous and non-squamous cell lung carcinoma
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DOI：
10.1016/j.lungcan.2006.08.011
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发表时间：
2006-12-01
期刊：
影响因子：
5.3
通讯作者：
Fuezesi, Laszlo
中科院分区：
文献类型：
--
作者：
Yakut, Tahsin;Schulten, Hans-Juergen;Fuezesi, Laszlo
尽管对肺癌的肿瘤生物学已经有了相当多的了解，但仍有必要对该疾病的临床管理进行分子事件的评估。我们通过比较基因组杂交（CGH）研究了45例非小细胞肺癌（NSCLC）的染色体失衡模式，并将结果与包括表皮免疫组织化学（IHC）表达在内的临床病理特征相关联。生长因子受体。21例为鳞状细胞癌（SCC）， 24例为非鳞状细胞肺癌（NSCC），其中腺癌（ADC） 9例，大细胞癌（LCC） 9例，肉瘤样癌4例，腺鳞癌2例。个体失衡的平均数量SCC为7.1（平均增益，3.8；平均损失，3.4），NSCC为6.4（平均增益，4.5；平均损失，1.9）。几个个体失衡与失衡数量的增加显著相关，即+1q、-3p、+3q、-5q、-8p、+8q、+7p、+12p和+14q。,最常见的失衡+ 3 q (49%), p + 5(49%)、5 q (36%), + 8 q (29%), 8 p(24%)、3 p (22%), + 7 p (22%), p + 12(22%)、q + 14 (20%) + 18 p (20%), + 1 q(18%), + 7问(18%)。其中，+3q和+18p与SCC显著相关，+5p和+14q与NSCC显著相关。值得注意的是，重叠不平衡包括SCC中的+3q26、+7p11和NSCC中的+1q21、+3q24、+12p11和+14q12。EGFR在鳞状细胞癌中的表达高于非鳞状细胞癌，且在整个系列中与+3q相关。此外，在整个系列中，+12p与除nsclc中淋巴结受累外的疾病进展以及与疾病进展（无论淋巴结受累与否）显著相关。总之，本研究对NSCLC组织学亚型的分子生物学特征做出了贡献，并通过对分子事件的评估，为最近出现的肺癌治疗新标志物的关注做出了贡献。2006爱思唯尔爱尔兰有限公司版权所有。
Although considerable knowledge exists on the tumor biology of lung cancer, there is still a need to assess molecular events for the clinical management of the disease. We studied the pattern of chromosomal imbalances in 45 non-small cell Lung carcinomas (NSCLC) by comparative genomic hybridization (CGH) and correlated the results with clinicopathological features including immunohistochemical (IHC) expression of the epidermal. growth factor receptor (EGFR). Twenty-one tumors were squamous cell carcinomas (SCC) and 24 non-squamous cell lung carcinomas (NSCC) comprising 9 adenocarcinomas (ADC), 9 large cell carcinomas (LCC), 4 sarcomatoid carcinomas and 2 adenosquamous carcinomas. The mean number of individual imbalances was 7.1 for SCC (mean gains, 3.8; mean tosses, 3.4) and 6.4 for NSCC (mean gains, 4.5; mean tosses, 1.9). Several individual imbalances correlated significantly with increasing number of imbalances, that were +1q, -3p, +3q, -5q, -8p, +8q, +7p, +12p, and +14q. Altogether, the most frequent imbalances were +3q (49%), +5p (49%), -5q (36%), +8q (29%), -8p (24%), -3p (22%), +7p (22%), +12p (22%), +14q (20%), +18p (20%), +1q (18%), and +7q (18%). Among these, +3q and +18p correlated significantly with SCC, and +5p and +14q with NSCC. Remarkably, overlapping imbalances included +3q26, +7p11 in SCC and +1q21, +3q24, +12p11, and +14q12 in NSCC. EGFR expression was higher in SCC than in NSCC and correlated with +3q in the entire series. In addition, +12p correlated significantly with disease progress with the exception of nodal involvement in NSCC as well as with disease progress, regardless of nodal involvement, in the entire series. In conclusion, the present study contributes to the molecular biological characterization of NSCLC histological subtypes and through evaluation of molecular events to the recently emergent focus on novel markers for lung cancer treatment. (C) 2006 Elsevier Ireland Ltd. All rights reserved.