Pulicatins A-E, Neuroactive Thiazoline Metabolites from Cone Snail-Associated Bacteria
Pulicatins A-E, Neuroactive Thiazoline Metabolites from Cone Snail-Associated Bacteria
复制标题
DOI：
10.1021/np100588c
复制
发表时间：
2010-11-01
影响因子：
5.1
通讯作者：
Schmidt, Eric W.
中科院分区：
文献类型：
--
作者：
Lin, Zhenjian;Antemano, Rowena R.;Schmidt, Eric W.
The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca2+ flux. These compounds include known thiazoline compounds and a series of new derivatives, pulicatins A-E (6-10). Individual compounds were shown to hind to a series of human receptors, with selective binding to the human serotonin 5-HT2B receptor. Here, we report the structure elucidation of the new compounds and results of the neurological assays.
