The prevalence of prostate carcinoma and its precursor in Hungary: An autopsy study
The prevalence of prostate carcinoma and its precursor in Hungary: An autopsy study
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DOI：
10.1016/j.eururo.2005.08.010
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发表时间：
2005-11-01
期刊：
影响因子：
23.4
通讯作者：
Dezso, B
中科院分区：
文献类型：
--
作者：
Soos, G;Tsakiris, I;Dezso, B
目的：评估匈牙利人（中欧高加索人）尸检系列中偶发性前列腺腺癌 (PCa) 及其前体高级别上皮内瘤变 (HGPIN) 的患病率，并与美国和欧洲国家的类似数据进行比较。方法：对无泌尿系统疾病史的尸检病例（n = 139；18-95 岁）进行组织学检查 前列腺癌和 HGPIN。整块取出后，将前列腺固定在福尔马林中，以35mm间隔切片并包埋在石蜡中。整体连续切片用苏木精-伊红染色并检查 PCa 和 HGPIN 的存在。将 PCa 和 HGPIN 的频率与从其他地理区域获得的尸检数据进行比较。结果：我们发现偶发性 PCa 的患病率为 38.8%，且与年龄相关的发病率不断增加。 PCa 和 HGPIN 均在 30 年代首次检测到，并且随着年龄的增长，病灶数量、肿瘤等级和体积呈现稳定增加。在81-95岁年龄组中，86.6%和60%的男性分别患有PCa和HGPIN。结论：偶发性PCa和HGPIN在匈牙利人群中非常普遍，与美国和斯堪的纳维亚白人的高流行病学数据相当。 (c) 2005 Elsevier B.V. 保留所有权利。
Objectives: The prevalence of incidental prostatic adenocarcinoma (PCa) and its precursor, high grade intraepithelial neoplasia (HGPIN) in an autopsy series from Hungarians (Central European Caucasians) was assessed and compared to similar data from the United States and European countries.Methods: Autopsy cases (n = 139; 18-95 years) with no history of urological disease were histologically examined for prostate cancer and HGPIN. After en block removal, the prostate glands were fixed in formalin, sectioned at 35 mm intervals and embedded in paraffin. Whole-mount serial sections were stained with Hematoxylin-eosin and examined for the presence of PCa and HGPIN. The frequency of PCa and HGPIN was compared to autopsy data obtained from other geographical areas.Results: We found a 38.8% prevalence of incidental PCa with increasing age-related incidence. Both PCa and HGPIN are first detected in the 3rd decade and show a steady increase with age with respect to number of foci, tumor Grade and volume. In the age group 81-95, 86.6% and 60% of men had PCa and HGPIN, respectively.Conclusions: Incidental PCa and HGPIN are very prevalent in Hungarian population, comparable with the high US and the Scandinavian epidemiological data for Caucasians. (c) 2005 Elsevier B.V. All rights reserved.