Overview: Ticks as vectors of pathogens that cause disease in humans and animals
Overview: Ticks as vectors of pathogens that cause disease in humans and animals
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DOI：
10.2741/3200
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发表时间：
2008-05-01
影响因子：
3.1
通讯作者：
Sonenshine, Daniel E.
中科院分区：
文献类型：
--
作者：
de la Fuente, Jose;Estrada-Pena, Agustin;Sonenshine, Daniel E.
硬蜱可传播多种病原体给脊椎动物，包括病毒、细菌、原生动物和蠕虫。扁虱传播的病原体被认为是世界各地超过10万例人类疾病的罪魁祸首。扁虱被认为是仅次于蚊子的全球第二大人类疾病传播媒介，但它们是家畜和野生动物中最重要的致病病原体媒介。在硬蜱和脊椎动物宿主中，病原体的感染和发展都是由硬虱-病原体界面上的分子机制调节的。这些机制既涉及扁虱的特征，也涉及病原体的特征，包括共同特征和物种特有特征的进化。壁虱-病原体界面的分子表征正在迅速发展，并为开发防治壁虱感染及其相关病原体的新策略提供了新途径。
Ticks (Acari: Ixodidae) transmit a wide variety of pathogens to vertebrates including viruses, bacteria, protozoa and helminthes. Tick-borne pathogens are believed to be responsible for more than 100,000 cases of illness in humans throughout the world. Ticks are considered to be second worldwide to mosquitoes as vectors of human diseases, but they are the most important vectors of disease-causing pathogens in domestic and wild animals. Infection and development of pathogens in both tick and vertebrate hosts are mediated by molecular mechanisms at the tick-pathogen interface. These mechanisms, involving traits of both ticks and pathogens, include the evolution of common and species-specific characteristics. The molecular characterization of the tick-pathogen interface is rapidly advancing and providing new avenues for the development of novel control strategies for both tick infestations and their associated pathogens.