Genetic and epigenetic architecture of paternal origin contribute to gestation length in cattle
Genetic and epigenetic architecture of paternal origin contribute to gestation length in cattle
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DOI：
10.1038/s42003-019-0341-6
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发表时间：
2019-03-14
影响因子：
5.9
通讯作者：
Ma, Li
中科院分区：
文献类型：
--
作者：
Fang, Lingzhao;Jiang, Jicai;Ma, Li
妊娠期长短会影响后代的健康和生产性能。母体和胎儿的影响都会影响妊娠期长度；然而，父亲对妊娠长度的贡献仍然难以捉摸。利用27214头荷斯坦公牛的全基因组关联研究（GWAS），研究人员发现了9个与牛妊娠长度相关的父系基因组位点。我们证明这些GWAS信号在与胚胎发育相关的途径中丰富，并且在妊娠期长短的精子样本之间的差异甲基化区域中丰富。我们揭示了妊娠长度在精子中与产犊能力、体深和受孕率共享遗传和表观遗传结构。虽然在我们的精细定位分析中检测到几个候选基因，但我们提供的证据表明ZNF613是牛妊娠长度的有希望的候选基因。总的来说，我们的研究结果支持父系基因组和表观基因组可以通过调节胚胎发育潜在地影响妊娠长度。
The length of gestation can affect offspring health and performance. Both maternal and fetal effects contribute to gestation length; however, paternal contributions to gestation length remain elusive. Using genome-wide association study (GWAS) in 27,214 Holstein bulls with millions of gestation records, here we identify nine paternal genomic loci associated with cattle gestation length. We demonstrate that these GWAS signals are enriched in pathways relevant to embryonic development, and in differentially methylated regions between sperm samples with long and short gestation length. We reveal that gestation length shares genetic and epigenetic architecture in sperm with calving ability, body depth, and conception rate. While several candidate genes are detected in our fine-mapping analysis, we provide evidence indicating ZNF613 as a promising candidate for cattle gestation length. Collectively, our findings support that the paternal genome and epigenome can impact gestation length potentially through regulation of the embryonic development.