Opioid control of the fetal stretch response: implications for the first suckling episode.
Opioid control of the fetal stretch response: implications for the first suckling episode.
复制标题
阿片类药物对胎儿牵张反应的控制：对第一次哺乳期的影响。
DOI：
10.1037//0735-7044.106.5.866
复制
发表时间：
1992
影响因子：
1.9
通讯作者：
Robinson,SR
中科院分区：
文献类型：
--
作者：
Smotherman,WP;Robinson,SR
在它们第一次喝牛奶的时候，胎鼠表达了一种拉伸反应，这种反应类似于出生后幼鼠在乳头处表现出的行为。胎儿还拥有一个功能性阿片系统，该系统被产前母乳暴露激活。阿片受体拮抗剂纳洛酮和特异性kappa拮抗剂nor-binaltorphimine阻断了牵张反应，并阻止了通常由牛奶引起的后肢活动增加。mu拮抗剂β-funalcidamine阻断了牵拉，同时允许后肢活动的表达。κ激动剂U 50，488在没有乳汁的情况下促进后肢活动，而μ激动剂[{d}-Ala-2，NMe-Phe-4，Gly-5-ol]-脑啡肽（DAMGO）对胎儿行为几乎没有影响。用U 50，488预处理的胎儿拉伸到非牛奶刺激（盐水或柠檬），但用DAMGO预处理的胎儿没有。阿片样物质激活是在胎儿牵拉反应中达到高潮的一系列事件的一部分，并且可能在新生儿第一次哺乳期间促进乳汁摄入方面很重要。（PsycInfo数据库记录（c）2016阿帕，保留所有权利）
On their 1st experience with milk, fetal rats express a stretch response that is similar to the postnatal behavior exhibited by infant rats at the nipple. Fetuses also possess a functional opioid system that is activated by prenatal milk exposure. The opioid receptor antagonist naloxone and the specific kappa antagonist nor-binaltorphimine blocked the stretch response and prevented the increase in rearlimb activity that is typically induced by milk. The mu antagonist β-funaltrexamine blocked the stretch while permitting the expression of rearlimb activity. The kappa agonist U50, 488 promoted rearlimb activity in the absence of milk, whereas the mu agonist [{d}-Ala–2, NMe-Phe–4, Gly–5-ol]-enkephalin (DAMGO) exerted little influence on fetal behavior. Fetuses pretreated with U50, 488 stretched to nonmilk stimuli (saline or lemon), but fetuses pretreated with DAMGO did not. Opioid activation is part of a chain of events that culminates in the fetal stretch response and may be important in promoting milk ingestion during the newborn's 1st suckling episode.(PsycINFO Database Record (c) 2016 APA, all rights reserved)