Long-Term Exposure to Environmentally Relevant Doses of Large Polystyrene Microplastics Disturbs Lipid Homeostasis via Bowel Function Interference
Long-Term Exposure to Environmentally Relevant Doses of Large Polystyrene Microplastics Disturbs Lipid Homeostasis via Bowel Function Interference
复制标题
长期接触环境相关剂量的大聚苯乙烯微塑料会通过干扰肠道功能扰乱脂质稳态
DOI：
10.1021/acs.est.1c07933
复制
发表时间：
2022-10-25
影响因子：
11.4
通讯作者：
Chen, Da
中科院分区：
文献类型：
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作者：
Deng, Yongfeng;Chen, Hexia;Chen, Da
长期慢性暴露于微塑料（MP）是否会在哺乳动物中引起剂量和大小依赖性不良反应的问题仍然存在争议，而且人们对此知之甚少。我们的研究通过小鼠模型和粪便微生物宏基因组和血浆脂质组中断的综合分析，探讨了饮食暴露于环境相关剂量的聚苯乙烯（PS）MP的潜在健康风险。暴露于MP（40-100 μ m）21周后，小鼠主要表现出肠道微生物群失调、组织炎症和血浆脂质代谢紊乱，尽管在肠道或肝脏中没有观察到MP的显著积累。微生物群相对丰度的变化与MP的暴露剂量和大小密切相关，而肠道损伤和脂质代谢异常的影响不太显著。此外，多组学数据表明，宿主脂质代谢异常与肠道功能紊乱密切相关，包括肠道微生物群失调，肠道通透性增加和MP诱导的炎症。我们首次发现，即使在小鼠组织中没有明显的积累，长期暴露于环境相关剂量的MP仍然可能引起广泛的健康风险。这引起了人们对人类和其他哺乳动物暴露于环境相关剂量MP的健康风险的关注。
The question of whether long-term chronic exposure to microplastics (MPs) could induce dose-and size-dependent adverse effects in mammals remains controversial and poorly understood. Our study explored potential health risks from dietary exposure to environmentally relevant doses of polystyrene (PS) MPs, through a mouse model and integrated analyses of the interruptions of fecal microbial metagenomes and plasma lipidomes. After 21 weeks of exposure to the MPs (40-100 mu m), mice mainly exhibited gut microbiota dysbiosis, tissue inflammation, and plasma lipid metabolism disorder, although no notable accumulation of MPs was observed in the gut or liver. The change of the relative abundance of microbiota was strongly associated with the exposure dose and size of MPs while less significant effects were observed in gut damage and abnormal lipid metabolism. Moreover, multiomics data suggested that the host abnormal lipid metabolism was closely related to bowel function disruptions, including gut microbiota dysbiosis, increased gut permeability, and inflammation induced by MPs. We revealed for the first time that even without notable accumulation in mouse tissues, long-term exposure to MPs at environmentally relevant doses could still induce widespread health risks. This raises concern on the health risks from the exposure of humans and other mammals to environmentally relevant dose MPs.