Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses
Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses
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DOI：
10.1016/j.immuni.2009.06.016
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发表时间：
2009-08-21
期刊：
影响因子：
32.4
通讯作者：
Brink, Robert
中科院分区：
文献类型：
--
作者：
Gatto, Dominique;Paus, Didrik;Brink, Robert
体液免疫依赖于针对入侵病原体的快速和长期的抗体产生。这是通过产生在空间上不同的滤泡外浆母细胞和滤泡生发中心（GC）B细胞群来实现的，但引导应答B细胞进入这些不同区域的信号尚未完全阐明。在此，我们表明活化的B细胞表达孤儿G蛋白偶联受体爱泼斯坦 - 巴尔病毒诱导基因2（EBI2，也称为GPR183）对其迁移到滤泡外部位以及诱导早期浆母细胞反应至关重要。相反，EBI2的下调使B细胞能够进入滤泡中心并促进有效的生发中心形成。因此，EBI2为B细胞迁移提供了一个以前未被描述的维度，这对协调快速和长期的抗体反应至关重要。
Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC) B cell populations, but the signals that guide responding B cells to these alternative compartments have not been fully elucidated. Here, we show that expression of the orphan G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2, also known as GPR183) by activated B cells was essential for their movement to extrafollicular sites and induction of early plasmablast responses. Conversely, downregulation of EBI2 enabled B cells to access the center of follicles and promoted efficient GC formation. EBI2 therefore provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses.