Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes
Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes
复制标题
DOI：
10.1139/o02-153
复制
发表时间：
2002-01-01
影响因子：
2.9
通讯作者：
Cass, CE
中科院分区：
文献类型：
--
作者：
Cabrita, MA;Baldwin, SA;Cass, CE
编码核苷转运蛋白的 cDNA 的分子克隆极大地促进了对核苷渗透物如何跨细胞膜转运的理解。迄今为止鉴定的核苷转运蛋白已分为五个不同的超家族。其中两个超家族，即平衡核苷转运蛋白和集中核苷转运蛋白，都有人类成员，本综述将深入研究这些超家族。人类平衡核苷转运蛋白沿着其浓度梯度双向移位核苷和核碱基，对于抗癌和抗病毒核苷药物的摄取很重要。人类集中核苷转运蛋白逆着核苷浓度梯度单向共转运核苷和钠，并在某些组织中发挥重要作用。由于有更多工具可供使用，核苷和核碱基转运蛋白的调节正在得到更深入的研究。本综述概述了分子生物学以及核苷和核碱基转运蛋白调控的最新进展。
The molecular cloning of cDNAs encoding nucleoside transporter proteins has greatly advanced understanding of how nucleoside permeants are translocated across cell membranes. The nucleoside transporter proteins identified thus far have been categorized into five distinct superfamilies. Two of these superfamilies, the equilibrative and concentrative nucleoside transporters, have human members and these will be examined in depth in this review. The human equilibrative nucleoside transporters translocate nucleosides and nucleobases bidirectionally down their concentration gradients and are important in the uptake of anticancer and antiviral nucleoside drugs. The human concentrative nucleoside transporters cotranslocate nucleosides and sodium unidirectionally against the nucleoside concentration gradients and play a vital role in certain tissues. The regulation of nucleoside and nucleobase transporters is being studied more intensely now that more tools are available. This review provides an overview of recent advances in the molecular biology and regulation of the nucleoside and nucleobase transporters.