Harnessing Growth Factors to Influence Wound Healing
Harnessing Growth Factors to Influence Wound Healing
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DOI：
10.1016/j.cps.2012.04.003
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发表时间：
2012-07-01
影响因子：
2.3
通讯作者：
Eriksson, Elof
中科院分区：
文献类型：
--
作者：
Kiwanuka, Elizabeth;Junker, Johan;Eriksson, Elof
皮肤伤口愈合是一个动态过程，最终目标是恢复皮肤完整性。在皮肤损伤时，炎性细胞、内皮细胞、成纤维细胞和角质形成细胞经历基因表达和表型的变化，导致细胞增殖、迁移和分化。细胞因子和生长因子在启动和指导伤口愈合阶段中发挥重要作用。这些信号肽由多种细胞产生，并导致协调一致的努力来恢复皮肤屏障功能。
Cutaneous wound healing is a dynamic process with the ultimate goal of restoring skin integrity. On injury to the skin, inflammatory cells, endothelial cells, fibroblasts, and keratinocytes undergo changes in gene expression and phenotype, leading to cell proliferation, migration, and differentiation. Cytokines and growth factors play an essential role in initiating and directing the phases of wound healing. These signaling peptides are produced by a variety of cells and lead to a concerted effort to restore the skin barrier function.