The role of the left anterior temporal lobe in language processing revisited: Evidence from an individual with ATL resection
The role of the left anterior temporal lobe in language processing revisited: Evidence from an individual with ATL resection
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DOI：
10.1016/j.cortex.2009.12.002
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发表时间：
2011-05-01
期刊：
影响因子：
3.6
通讯作者：
Caramazza, Alfonso
中科院分区：
文献类型：
--
作者：
Bi, Yanchao;Wei, Tao;Caramazza, Alfonso
关于前颞叶（ATL）在语言加工中的作用已经提出了各种假说。一个假设是，它绑定的语义/概念属性的话，作为一个枢纽连接特定的情态概念属性的对象。这一假说预测，损害ATL会导致受损的概念知识的所有类别。一个相关学派的假设认为，左ATL是关键的词汇检索，不同的子区域可能对不同类别的项目重要。我们通过研究一例因低级别胶质瘤（LGG）而手术切除左ATL的病例来检验这些假设。手术后4个月进行的全面语言评估显示了以下情况：患者对所有类别的项目都显示出完整的概念知识，使用准确性和反应潜伏期措施进行测试;他对专有名称（人和地名）和人工制品（包括工具）的名称检索缺陷，但对有生命的东西没有名称检索困难。这种模式的结果挑战了两个目标假设的作用，ATL在语言处理测试这里。(C)2009 Elsevier Srl. All rights reserved.
Various hypotheses about the role of the anterior temporal lobe (ATL) in language processing have been proposed. One hypothesis is that it binds the semantic/conceptual properties of words, functioning as a hub for linking modality-specific conceptual properties of objects. This hypothesis predicts that damage to ATL would give rise to impaired conceptual knowledge of all categories. A related school of hypotheses assumes that the left ATL is critical for lexical retrieval, with different sub-regions potentially important for different categories of items. We examined these hypotheses by studying a case of surgical resection of left ATL due to a low-grade glioma (LGG). Thorough language assessments performed four months after the operation revealed the following profile: the patient showed intact conceptual knowledge for all categories of items tested using both accuracy and response latency measures; he suffered from name retrieval deficits for proper names (people and place names) and artifacts (including tools), but showed no name retrieval difficulties for animate things. This pattern of results challenges both target hypotheses about the role of ATL in language processing tested here. (C) 2009 Elsevier Srl. All rights reserved.