Age-related deficits as working memory load increases: relationships with growth factors
Age-related deficits as working memory load increases: relationships with growth factors
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DOI：
10.1016/s0197-4580(02)00015-5
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发表时间：
2003-01-01
影响因子：
4.2
通讯作者：
Granholm, ACE
中科院分区：
文献类型：
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作者：
Bimonte, HA;Nelson, ME;Granholm, ACE
年轻和老年雌性大鼠进行了测试的水径向臂迷宫，旨在衡量性能的工作记忆负荷增加，脑源性神经营养因子（BDNF），神经生长因子（NGF），神经营养因子3（NT 3）的蛋白质评估海马和额叶皮质。老年大鼠的工作记忆和参考记忆都有缺陷。也有深刻的年龄相关的工作记忆负荷的影响。随着工作记忆负荷的增加，老年大鼠会犯更多的错误，并且只在记忆负荷较低的早期试验中表现出学习能力，而年轻大鼠在所有试验中都表现出学习能力。神经营养因子评估显示，额叶皮层NGF和BDNF水平呈正相关，海马NT3呈负相关，与老年动物在特定试验期间所犯错误的数量相关。与未测试的大鼠相比，测试增加了两个年龄组的NT 3蛋白水平，但没有BDNF或NGF。研究结果表明，年轻大鼠学习处理更高的工作记忆负荷的测试进展，而老年大鼠没有，额叶皮层和海马神经营养因子水平可能与老年雌性大鼠的工作记忆能力。(C)2002年爱思唯尔科技有限公司All rights reserved.
Young and aged female rats were tested on a water radial-arm maze designed to measure performance as working memory load increased, followed by brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin 3 (NT3) protein assessments in hippocampus and frontal cortex. Aged rats showed deficiencies in both working and reference memory. There were also profound age-related working memory load effects. Aged rats made more errors as working memory load increased and showed learning only during early trials when memory load was low, while young rats exhibited learning over all trials. Neurotrophin assessment showed that frontal cortex NGF and BDNF levels were positively, and hippocampal NT3 negatively, correlated with number of errors made during specific trials in aged animals. Comparison to untested rats showed that testing increased NT3, but not BDNF or NGF, protein levels in both age groups. Findings suggest that young rats learn to handle a higher working memory load as testing progresses, while aged rats do not, and that frontal cortex and hippocampal neurotrophin levels may relate to working memory proficiency in aged female rats. (C) 2002 Elsevier Science Inc. All rights reserved.