A case of hyperosmolar nonketotic coma occurring during chemotherapy using cisplatin for gallbladder cancer.
A case of hyperosmolar nonketotic coma occurring during chemotherapy using cisplatin for gallbladder cancer.
复制标题
胆囊癌顺铂化疗期间发生高渗性非酮症昏迷一例。
作者：
C. Sakakura;A. Hagiwara;Syuichi Kin;K. Yamamoto;K. Okamoto;Toshiharu Yamaguchi;K. Sawai;H. Yamagishi
一名61岁女性因腹部肿瘤入院。她被诊断患有复发性胆囊癌，并接受顺铂（CDDP）治疗。第一个周期化疗后的第 6 天，她出现意识混乱并突然昏迷。第 7 天，她被诊断为高渗性非酮症昏迷 (HNC)。她没有糖尿病史。经过连续输注 0.45% 生理盐水和适量胰岛素 3 天后，她的 HNC 痊愈。 HNC 可能是恶性肿瘤患者 CDDP 化疗的并发症。对于恶性疾病化疗期间发生的 HNC，需要早期诊断和适当的治疗。
A 61 year-old woman was admitted to our hospital because of an abdominal tumor. She was diagnosed with recurrent gallbladder cancer, and treated with cisplatin (CDDP). On day 6, after the 1st cycle of chemotherapy, she developed confusion and suddenly became comatose. She was diagnosed as having hyperosmolar nonketotic coma (HNC) on day 7. She had no history of diabetes mellitus. She recovered from HNC after 3 days of treatment with continuous infusion of 0.45% saline and moderate amounts of insulin. HNC may be a complication of CDDP chemotherapy in patients with malignancy. Early diagnosis and appropriate treatment is necessary for HNC occurring during chemotherapy for malignant disease.