Synthesis of the DE-ring of goniodomin A and prediction of its natural relative stereochemistry
Synthesis of the DE-ring of goniodomin A and prediction of its natural relative stereochemistry
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DOI：
10.1016/j.tetlet.2007.11.084
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发表时间：
2008-01-07
影响因子：
1.8
通讯作者：
Suzuki, Takanori
中科院分区：
文献类型：
--
作者：
Katagiri, Takahiro;Fujiwara, Kenshu;Suzuki, Takanori
Goniodomin A (1) 于 1987 年首次由 Murakami 从 Alexandrium hiranoi 中分离出来，作为一种立体化学未鉴定的抗真菌剂。本研究合成了I的两个立体异构系列的非大环和大环DE环模型化合物，并通过I与这些模型化合物的NMR比较预测了DE环的天然相对立体化学。 (c) 2007 Elsevier Ltd. 保留所有权利。
Goniodomin A (1) was first isolated from Alexandrium hiranoi as a stereochemically unidentified antifungal agent in 1987 by Murakami. In this study, two stereoisomeric series of non-macrocyclic and macrocyclic DE-ring model compounds of I were synthesized, and the natural relative stereochemistry of the DE-ring was predicted by NMR comparison of I with these model compounds. (c) 2007 Elsevier Ltd. All rights reserved.