REAL-TIME MONITORING OF ELECTRICALLY STIMULATED NOREPINEPHRINE RELEASE IN RAT THALAMUS .2. MODELING OF RELEASE AND REUPTAKE CHARACTERISTICS OF STIMULATED NOREPINEPHRINE OVERFLOW
REAL-TIME MONITORING OF ELECTRICALLY STIMULATED NOREPINEPHRINE RELEASE IN RAT THALAMUS .2. MODELING OF RELEASE AND REUPTAKE CHARACTERISTICS OF STIMULATED NOREPINEPHRINE OVERFLOW
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DOI：
10.1111/j.1471-4159.1993.tb03171.x
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发表时间：
1993-02-01
影响因子：
4.7
通讯作者：
WIGHTMAN, RM
中科院分区：
文献类型：
--
作者：
CAPELLA, P;GHASEMZADEH, MB;WIGHTMAN, RM
与前面的研究一样，使用电刺激来影响去甲肾上腺素在大鼠丘脑中的释放溢出。使用碳纤维电极的弱电化学前处理，可以在没有代谢物干扰的情况下“调谐”去甲肾上腺素的电化学响应信号。然后，这个合理选择的信号被用来研究长时间刺激引起的去甲肾上腺素释放能力的下降。此外，这些信号被成功地用于刺激性多巴胺溢出的方法建模，提供了迄今为止关于去甲肾上腺素释放溢出的时间和空间特征的信息。多巴胺和去甲肾上腺素系统释放特性的相关性比较表明，去甲肾上腺素在细胞外液中的半衰期在丘脑中约为1 S，而在尾状核中为33ms。
As in the preceding study, electrical stimulation was used to effect release overflow of norepinephrine in the rat thalamus. Using a weak electrochemical pretreatment of a carbon fiber electrode, it was possible to ''tune in'' the electrochemical response signal for norepinephrine without metabolite interference. This reasonably selective signal was then used to study the degradation of norepinephrine release ability caused by prolonged stimulation. Further, the signals were modeled by the method used successfully for stimulated dopamine overflow, providing hitherto unavailable information on the temporal and spatial characteristics of norepinephrine release overflow. Pertinent comparisons between the release characteristics of the dopamine and norepinephrine systems show that the half-life for norepinephrine in the extracellular fluid space is approximately 1 s in thalamus compared with 33 ms for dopamine in caudate.