Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain.
Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain.
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DOI：
10.3390/ijerph13010146
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发表时间：
2016-01-20
影响因子：
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通讯作者：
Fraser W
中科院分区：
文献类型：
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作者：
Ashley-Martin J;Dodds L;Arbuckle TE;Morisset AS;Fisher M;Bouchard MF;Shapiro GD;Ettinger AS;Monnier P;Dallaire R;Taback S;Fraser W
全氟烷基物质(PFAS)是一种普遍存在的持久性污染物，广泛用于普通家用和消费品的生产。有限的文献表明，这些化学物质可能会改变新陈代谢途径和生长轨迹。产前暴露于这些化学物质与妊娠体重增加(GWG)之间的关系受到的关注有限。一个目的是分析三种常见的全氟烷基物质(全氟辛酸(PFOA)、全氟辛烷磺酸(PFOS)、全氟己烷磺酸(PFHxS))与GWG之间的关系。此外，我们还探讨了GWG是否与脐带血PFAS水平有关。这项研究利用了母婴环境化学品研究(MIREC)研究中收集的数据，这是一项跨加拿大对2001名孕妇进行的队列研究。我们的分析量化了(1)母体PFAS浓度和GWG之间的关系，以及(2)GWG和脐带血PFAS浓度之间的关系。母血全氟辛烷磺酸浓度与GWG呈正相关(β=0.39，95%CI：0.02，0.75)。GWG的四分位数增加与脐血全氟辛酸(OR=1.33；95%CI：1.13至1.56)和全氟辛烷磺酸(OR=1.20；95%CI：1.03至1.40)浓度升高显著相关。未观察到GWG与PFHxS的任何一项指标之间有统计学意义的关联。这些发现需要阐明潜在的潜在机制。
Perfluoroalkyl substances (PFASs) are ubiquitous, persistent pollutants widely used in the production of common household and consumer goods. There is a limited body of literature suggesting that these chemicals may alter metabolic pathways and growth trajectories. The relationship between prenatal exposures to these chemicals and gestational weight gain (GWG) has received limited attention. One objective was to analyze the associations among maternal plasma levels of three common perfluoroalkyl substances (perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfanoate (PFHxS)) and GWG. Additionally, we explored whether GWG was associated with cord blood PFAS levels. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analysis quantified associations between (1) maternal PFAS concentrations and GWG and (2) GWG and cord blood PFAS concentrations. Maternal PFOS concentrations were positively associated with GWG (β = 0.39 95% CI: 0.02, 0.75). Interquartile increases in GWG were significantly associated with elevated cord blood PFOA (OR = 1.33; 95% CI: 1.13 to 1.56) and PFOS (OR = 1.20; 95% CI: 1.03 to 1.40) concentrations. No statistically significant associations were observed between GWG and either measure of PFHxS. These findings warrant elucidation of the potential underlying mechanisms.