Impact of a weight loss program on migraine in obese adolescents
Impact of a weight loss program on migraine in obese adolescents
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DOI：
10.1111/j.1468-1331.2012.03771.x
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发表时间：
2013-02-01
影响因子：
5.1
通讯作者：
Battistella, P. A.
中科院分区：
文献类型：
--
作者：
Verrotti, A.;Agostinelli, S.;Battistella, P. A.
背景和目的：在肥胖人群中观察到头痛频率和严重程度的增加，但减肥治疗对头痛的真正影响还没有研究。我们在肥胖青少年样本中调查了这一问题。方法：总共有135名年龄在14-18岁、体重指数(BMI)和体重指数(BMI)=97百分位数的偏头痛患者参加了为期12个月的治疗前后的研究。结果：在前6个月结束时，观察到体重(P<；0.01)、BMI(P<；0.01)、腰围(P<；0.01)、头痛频率(P<；0.01)和强度(P<；0.01)、急性药物的使用(P<；0.05)和残疾(P<；0.05)的下降，并持续到后6个月。较低的基线BMI和BMI的过度变化都与干预计划12个月后偏头痛预后的改善显著相关。结论：参加了为期12个月的跨学科减肥干预计划的肥胖青少年偏头痛患者的肥胖和头痛数据均有显著改善。初始体重和体重减少量可能有助于临床医生预测偏头痛的结果。
Background and purpose: Increased headache frequency and severity have been observed in obese populations, but the real impact of a weight loss treatment on headache has not been studied. We investigated this issue in a sample of obese adolescents.Methods: In all, 135 migraineurs, aged 14-18 years, with body mass index (BMI) >= 97th percentile, participating in a 12-month-long program, were studied before and after treatment. The program included dietary education, specific physical training, and behavioral treatment.Results: Decreases in weight (P < 0.01), BMI (P < 0.01), waist circumference (P < 0.01), headache frequency (P < 0.01) and intensity (P < 0.01), use of acute medications (P < 0.05), and disability (P < 0.05) were observed at the end of the first 6-month period and were maintained through the second 6 months. Both lower baseline BMI and excess change in BMI were significantly associated with better migraine outcomes 12 months after the intervention program.Conclusions: Significant improvements in both adiposity and headache data were observed in obese adolescents with migraine who participated in a 12-month-long interdisciplinary intervention program for weight loss. Initial body weight and amount of weight loss may be useful for clinicians to predict migraine outcomes.