Changing trends in the proportion of adenocarcinoma of the esophagogastric junction in a large tertiary referral center in Japan
Changing trends in the proportion of adenocarcinoma of the esophagogastric junction in a large tertiary referral center in Japan
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DOI：
10.1111/j.1440-1746.2008.05572.x
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发表时间：
2008-11-01
影响因子：
4.1
通讯作者：
Shimoda, Tadakazu
中科院分区：
文献类型：
--
作者：
Kusano, Chika;Gotoda, Takuji;Shimoda, Tadakazu
在过去的二十年中，西方报道了食管胃交界处腺癌（EGJ）的发病率急剧增加。然而，来自亚洲国家的流行病学数据并未显示出类似的趋势。本研究的目的是确定在日本一家主要癌症转诊中心连续接受胃腺癌手术的患者中EGJ腺癌的发生率。我们回顾了1962年至2005年间在东京国立癌症中心医院接受晚期胃腺癌手术的所有患者的病理报告。根据Siewert和Stein的分类，根据每位患者记录的图像定义EGJ腺癌。每隔5年统计胃腺癌手术患者中EGJ区腺癌的比例，并进行系列比较。手术治疗晚期胃腺癌患者6953例；EGJ腺癌520例。EGJ腺癌的总体比例从2.3%（1962-1965）上升到10.0%（2001-2005）。siwert II型的比例从28.5%（1962-1965）上升到57.3%(2001-2005)，而I型的比例保持在1%左右。本研究对日本某大型三级转诊中心1962 - 2005年间接受胃腺癌手术的患者进行了研究，发现EGJ腺癌呈上升趋势。
A dramatic increase in incidence of adenocarcinoma of the esophagogastric junction (EGJ) over the past two decades has been reported in the West. However, epidemiological data from Asian countries have not shown a similar trend. The aim of this study was to determine the incidence of adenocarcinoma of the EGJ in a cohort of consecutive patients operated on for gastric adenocarcinoma at a major cancer referral center in Japan.We reviewed pathological reports of all patients who underwent surgery for advanced gastric adenocarcinoma between 1962 and 2005 at the National Cancer Centre Hospital in Tokyo. Adenocarcinoma of the EGJ was defined from images recorded for each patient, in accordance with the classification of Siewert and Stein. The proportion of adenocarcinoma at the EGJ among operated gastric adenocarcinoma patients was compiled at five-year intervals and serial comparison made.A total of 6953 patients with advanced gastric adenocarcinoma were operated on; adenocarcinoma of EGJ was found in 520 patients. The overall proportion of adenocarcinoma of the EGJ increased from 2.3% (1962-1965) to 10.0% (2001-2005). The proportion of Siewert Type II rose from 28.5% (1962-1965) to 57.3% (2001-2005), while that of Type I remained at around 1%.An increasing trend of adenocarcinoma of EGJ is observed in this study of patients operated on for gastric adenocarcinoma from 1962 to 2005 in a large tertiary referral center in Japan.