Menière's disease and hydrochlorothiazide (Dichlotride)--a critical analysis of symptoms and therapeutic effects.
Menière's disease and hydrochlorothiazide (Dichlotride)--a critical analysis of symptoms and therapeutic effects.
复制标题
梅尼埃病和氢氯噻嗪（二氯噻嗪）——症状和治疗效果的批判性分析。
DOI：
10.3109/00016486709128769
复制
发表时间：
1967
影响因子：
1.4
通讯作者：
U. Lindblom
中科院分区：
文献类型：
--
作者：
I. Klockhoff;U. Lindblom
在50例梅尼埃病病例中，口服利尿剂Dichlotride®（氢氯噻嗪），目的是减少可能具有致病重要性的电解质紊乱和内淋巴积水。在20个案例中进行了试点研究。在疾病处于晚期稳定期的病例中，没有观察到任何效果，其中有“平坦损失”型的非波动性听力损失。在疾病仍有发作样或波动性病程的病例中，与治疗相结合获得了改善，但鉴于自发病程差异很大，结果尚不确定。因此，使用双盲技术对30例波动型病例进行了第二个治疗系列。每月记录症状的患病率和严重程度。听力采用纯音测听法，耳鸣、眩晕和一般情况采用固定量表分级。所有的症状，以及一般情况，显示出高...
In 50 cases of Meniere's disease, a diuretic, Dichlotride® (hydrochlorothiazide), was administered orally with the object of reducing the electrolyte disturbance and endolymphatic hydrops that can be presumed to be of pathogenetic importance. A pilot study was made in 20 cases. No effect was noted in cases in which the disease was in a late stationary stage, with non-fluctuating hearing loss of the “flat loss” type. In cases in which the disease still had a bout-like or fluctuating course, an improvement was obtained in connexion with therapy, but the results were inconclusive, in view of the greatly varying spontaneous course. A second treatment series was therefore carried out, using the double-blind technique, in 30 cases of the fluctuating type. The prevalence and intensity of the symptoms were recorded monthly. The hearing was measured by tone audiometry, whereas tinnitus, vertigo and general condition were graded according to fixed scales. All symptoms, as well as the general condition, showed a hig...