SHARED NEURAL SUBSTRATES CONTROLLING HAND MOVEMENTS IN HUMAN MOTOR CORTEX
SHARED NEURAL SUBSTRATES CONTROLLING HAND MOVEMENTS IN HUMAN MOTOR CORTEX
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DOI：
10.1126/science.7792606
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发表时间：
1995-06-23
期刊：
影响因子：
56.9
通讯作者：
WARACH, S
中科院分区：
文献类型：
--
作者：
SANES, JN;DONOGHUE, JP;WARACH, S
人类的随意手部运动涉及初级运动皮层（M1）。一种功能磁共振成像方法，测量相对脑血流量被用来确定一个分布式的，重叠模式的手运动表示内的后中央前回，其中包含M1。观察到的模式类似于那些在非人类灵长类动物中报道的模式，并且不同于通常用于描绘人类运动皮层组织的躯体位置组织计划。手指和手腕的运动激活了广泛的中央前回后，和代表不同的手指运动重叠彼此和手腕的代表。在所有运动中，中央前回都有多个激活部位。重叠表示可能介导运动和认知功能，需要协调的神经处理手指和手腕的动作，而不是离散控制暗示的躯体位置图。
Voluntary hand movements in humans involve the primary motor cortex (M1). A functional magnetic resonance imaging method that measures relative cerebral blood flow was used to identify a distributed, overlapping pattern of hand movement representation within the posterior precentral gyrus, which contains M1. The observed pattern resembles those reported in nonhuman primates and differs from a somatotopically organized plan typically used to portray human motor cortex organization. Finger and wrist movements activated a wide expanse of the posterior precentral gyrus, and representations for different finger movements overlapped each other and the wrist representation. Multiple sites of activation occurred in the precentral gyrus for all movements. The overlapping representations may mediate motor and cognitive functions requiring coordinated neural processing for finger and wrist actions rather than discrete control implied by somatotopic maps.