Patterns of improvement in spirometry, bronchial hyperresponsiveness, and specific IgE antibody levels after cessation of exposure in occupational asthma caused by snow-crab processing.
Patterns of improvement in spirometry, bronchial hyperresponsiveness, and specific IgE antibody levels after cessation of exposure in occupational asthma caused by snow-crab processing.
复制标题
停止接触雪蟹加工引起的职业性哮喘后，肺活量测定、支气管高反应性和特异性 IgE 抗体水平的改善模式。
DOI：
10.1164/ajrccm/138.4.807
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Lehrer,SB
中科院分区：
文献类型：
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作者：
Malo,JL;Cartier,A;Ghezzo,H;Lafrance,M;McCants,M;Lehrer,SB
对31名因雪蟹加工引起职业性哮喘的工人进行了3次长期随访，随访时间平均±SO间隔分别为12.8±5.4、31.4±6.3和64.4±6.3个月。工作相关哮喘的诊断最初是通过工作场所的特定吸入挑战或实验室吸入雪蟹沸水（n = 24）或通过在工作和下班时连续监测气道口径和支气管对组胺的反应性（n = 7）来确诊的。工作相关暴露总持续时间为12.8±5.6个月（范围为3～21个月），发病后症状持续时间为6.8±4.2个月（范围为1～18个月）。在诊断时，所有 31 名受试者都需要治疗哮喘药物，其中 11 名受试者的 FEV1 预计为 850/0，所有受试者的 PC 值均为 16 mg/ml。评估的 25 份血清样本中的 12 份显示出高水平的针对蟹肉和/或沸水的特异性免疫球蛋白 E (lgE) 抗体。在第一次随访时，需要药物治疗的受试者数量有所减少，其中FEV”和 PC，...16 毫克/毫升。然而，此后没有观察到进一步的变化。同样，平均 FEV 和
Thirty-one workers with occupational asthma caused by snow-crab processing were assessed by a long-term follow-up on three occasions at mean±SOIntervals of 12.8±5.4, 31.4±6.3, and 64.4±6.3 months after leaving work. The diagnosis of work-related asthma was initially confirmed In all of them by specific Inhalation challenges at the workplaca or by laboratory Inhalation of snow-crab boiling water (n= 24) or by serial monitoring of airway caliber and bronchial responsiveness to histamine at work and off work (n= 7). Total duration of work-related exposure was 12.8±5.6 months (range, 3 to 21 months), and the duration of symptoms after onset was6.8±4.2 months (range, 1 to 18months). At the time of diagnosis, all 31SUbjectsrequired medication for asthma, 11 had a FEV,.. 850/0 predicted, and all subjects had a PC".. 16 mg/ml. Twelve of 25 serum samples assessed showed high levels of specific Immunoglobulin E (lgE) antibodies to crab meat and/or boiling water. At the time of the first follow-up, there was a reduction in the number of subjects stili requiring medication, with a significant reduction in FEV" and a PC,...16 mg/ml. Howaver, no further change was observed afterwards. Similarly, the mean FEV, and