Severe retinal vasculitis in systemic lupus erythematosus leading to vision threatening paracentral acute middle maculopathy
Severe retinal vasculitis in systemic lupus erythematosus leading to vision threatening paracentral acute middle maculopathy
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DOI：
10.1080/24725625.2021.1893961
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发表时间：
2021-04-03
影响因子：
0.8
通讯作者：
Manghani, Mona
中科院分区：
文献类型：
--
作者：
Chin, Daniel;Gan, Nicola Y.;Manghani, Mona
系统性红斑狼疮可以影响任何器官系统在表现和整个过程中。狼疮视网膜血管炎是造成不同程度的视力丧失的原因，通常归因于毛细血管前浅表动脉血管的受累。利用多模态成像技术和电生理学，我们证明了有史以来第一例严重狼疮视网膜血管炎导致罕见的中央旁急性中间黄斑病变。结果显示视网膜浅层和深层毛细血管受累以及视网膜功能障碍的定位。这种精确的评估有助于及时使用联合免疫调节治疗和局部泛视网膜激光光凝，从而保护视力。
Systemic lupus erythematosus can affect any organ system at presentation and throughout its course. Lupus retinal vasculitis is responsible for the visual loss of variable severity and typically ascribed to the involvement of pre-capillary superficial arterial vasculature. Using multimodal imaging techniques and electrophysiology, we demonstrate the first-ever case of severe lupus retinal vasculitis resulting in the rare association of paracentral acute middle maculopathy. The findings showcase the involvement of both superficial and deep retinal capillary vasculature and the localisation of retinal dysfunction. This precise evaluation facilitated the timely use of combination immunomodulatory therapy with localised pan-retinal laser photocoagulation, resulting in the preservation of vision.