Circadian variation in nasal reactivity in children with allergic rhinitis: Correlation with the activity of eosinophils and basophilic cells
Circadian variation in nasal reactivity in children with allergic rhinitis: Correlation with the activity of eosinophils and basophilic cells
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DOI：
10.1159/000053604
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发表时间：
1999-01-01
影响因子：
2.8
通讯作者：
Kohno, Y
中科院分区：
文献类型：
--
作者：
Aoyagi, M;Watanabe, H;Kohno, Y
背景资料：在过敏性鼻炎中，流鼻涕，打喷嚏和鼻塞的主要症状往往在早上醒来时变得更糟，但这种现象背后的机制知之甚少。我们研究了早晨过敏性鼻炎的恶化是否与炎症细胞活性的变化有关。研究方法：对8例变应性鼻炎患儿和8例健康对照者分别于上午6时和下午3时测定鼻分泌物和外周血中嗜酸性粒细胞阳离子蛋白（ECP）、组胺和类胰蛋白酶的含量。结果：鼻反应性乙酰甲胆碱在上午6时，不仅在患者，而且在健康对照组更高。血清ECP和血浆组胺水平无昼夜节律。另一方面，在早上6点的鼻分泌物中发现了显著更高水平的炎症活化产物，因此显示出与鼻反应性的直接关联。结论：这些结果表明，鼻反应性的昼夜变化与鼻粘膜中嗜酸性粒细胞和嗜碱性细胞的活性变化有关。
Background: In allergic rhinitis, the major symptoms of runny nose, sneezing, and stuffy nose tend to become worse upon waking up in the morning, and yet the mechanisms underlying this phenomenon are poorly understood. We investigated whether the worsening of allergic rhinitis in the morning is associated with changes in the activity of inflammatory cells. Methods: Nasal reactivity to methacholine was assessed twice in 8 children with allergic rhinitis and 8 healthy control subjects at 6.00 a.m. and 3.00 p.m. The amounts of eosinophil cationic protein (ECP), histamine and tryptase in induced nasal secretions and peripheral blood were also measured. Results: Nasal reactivity to methacholine was higher at 6.00 a.m. not only in patients but also in healthy controls. Serum ECP and plasma histamine levels showed no circadian patterns. On the other hand, significantly higher levels of inflammatory activation products were found in nasal secretions at 6.00 a.m., thus showing a direct association with nasal reactivity. Conclusion: These results suggest that the circadian variation in nasal reactivity is associated with changes in the activity of eosinophils and basophilic cells in the nasal mucosa.