Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women
Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women
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DOI：
10.1002/art.20473
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发表时间：
2004-09-01
影响因子：
--
通讯作者：
Smith, MB
中科院分区：
文献类型：
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作者：
Mosher, TJ;Liu, Y;Smith, MB
Objective.由于软骨的磁共振成像（MRI）横向弛豫时间（T2）对软骨中胶原纤维的组织化敏感，因此它可能是软骨胶原老化变化和早期软骨退变的无创性图像标记。本研究的目的是确定健康无症状女性软骨T2值的年龄依赖性差异。使用3.0T MRI扫描仪获得30例年龄22-86岁无症状女性髌骨软骨的定量T2图。研究人群按年龄分为4个队列：18-30岁、31-45岁、46-65岁和66-86岁。软骨T2的空间差异被确定为与骨的归一化距离的函数。将老年组与18-30岁组进行比较，以确定年龄对软骨T2值的影响。如果组间T2平均值差异P <0.05，则认为区域差异有统计学意义。2个最年轻队列的平均软骨T2曲线几乎相同。与18-30岁组相比，46-65岁组浅表40%软骨T2值显著延长，66-86岁组整个软骨厚度T2值显著延长。45岁以上女性T2升高的位置与软骨胶原衰老变化开始于关节面附近并随着年龄增长进展至更深软骨的理论一致。
Objective. Because the magnetic resonance imaging (MRI) transverse relaxation time (T2) of cartilage is sensitive to organization of collagen fibers in the cartilage, it may be a noninvasive image marker for senescent changes in cartilage collagen and early cartilage degeneration. The purpose of this study was to determine age-dependent differences in cartilage T2 values in healthy asymptomatic women.Methods. Quantitative T2 maps of patellar cartilage from 30 asymptomatic women ages 22-86 years were obtained using a 3.0T MRI scanner. The study population was stratified by age into 4 cohorts: 18-30, 31-45, 46-65, and 66-86 years. Spatial differences in cartilage T2 were determined as a function of normalized distance from bone. Older groups were compared with the 18-30-year-old group to determine the effects of age on cartilage T2 values. Regions were considered statistically significantly different if the mean T2 values between groups differed at P < 0.05.Results. Mean cartilage T2 profiles were nearly identical for the 2 youngest cohorts. Compared with the 18-30-year-old group, T2 values were statistically significantly longer in the superficial 40% of cartilage in the 46-65-year-old group and over the entire cartilage thickness in the 66-86-year-old group.Conclusion. The location of T2 elevations in women over the age of 45 years is consistent with the theory that senescent changes of cartilage collagen begin near the articular surface and progress to the deeper cartilage with advancing age.