Plasmonic nanostructures for the ultrasensitive detection of biomolecules
Plasmonic nanostructures for the ultrasensitive detection of biomolecules
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DOI：
10.1393/ncr/i2016-10129-y
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发表时间：
2016-11-01
影响因子：
4.5
通讯作者：
Di Fabrizio, E.
中科院分区：
文献类型：
--
作者：
Das, G.;Coluccio, M. L.;Di Fabrizio, E.
本文描述的中心物理现象是不同类型的纳米结构中表面等离子体激元的光学产生。它决定了附近分子对入射和散射电磁场的局部增强。本文综述了不同的等离子体器件，它们的设计和空间布置与拉曼光谱或热电子成像相结合时提供了最佳的生物分子检测水平。作者获得的最新结果表明，有可能在全摩尔浓度范围内达到分析灵敏度，并具有分析特异性，以解决癌症检测实验中以单点突变为特征的复杂多肽混合物。在不同的背景下，利用绝热压缩现象，我们报告了在几个纳米的局域区域产生光和热电子源的可能性。它们的能量控制和精确的空间定位使得对物质的研究具有前所未有的准确性和丰富的信息。
The central physical phenomenon described in this paper is the optical generation of surface plasmon polaritons within different kinds of nanostructures. It determines the local enhancement of the incident and scattered electromagnetic field by nearby molecules. The paper reviews different plasmonic devices whose design and spatial arrangement offer an optimal detection level of biomolecules when combined with Raman spectroscopy or hot electrons imaging. Recent results, obtained by the authors, demonstrated that it is possible to reach an analytical sensitivity in the attomolar concentration range, with an analytical specificity to solve complex peptide mixtures characterized by single point mutation in cancer detection experiments. In a different context, exploiting the adiabatic compression phenomenon, we have reported the possibility to generate both light and hot electrons sources in a localized area of few nanometers. Their energy control and accurate spatial localization allow the investigation of matter with unprecedented accuracy and richness of information.