Living microtransporter by uni-directional gliding of Mycoplasma along microtracks
Living microtransporter by uni-directional gliding of Mycoplasma along microtracks
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DOI：
10.1016/j.bbrc.2005.03.168
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发表时间：
2005-05-27
影响因子：
3.1
通讯作者：
Uyeda, TQP
中科院分区：
文献类型：
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作者：
Hiratsuka, Y;Miyata, M;Uyeda, TQP
滑动的支原体细菌粘附在塑料表面上并剧烈地移动。然而，还无法控制平面上的运动方向。在这里，我们报告油图案光刻基板，M.移动细胞无法爬上高墙并沿着墙的底部边缘移动。这种沿着墙壁持续移动的特性使我们能够设计控制移动方向的图案，从而导致两个区域之间出现不良的单向循环或单向门控。此外，表面蛋白生物素化后装载有链霉亲和素珠的细胞以正常速度移动。这些细菌可用作活的微转运蛋白。在微米级空间内运载货物。 (c) 2005 Elsevier Inc. 保留所有权利。
The gliding bacterium Mycoplasma mobile adheres to plastic surfaces and mows around rigorously. However, it has not been possible to control the direction of movements on plain Surfaces. Here we report that oil patterned lithographic substrates, M. mobile cells are unable to climb tall walls and move along the bottom edge of the walls. This property, to move persistently along walls enabled us to design patterns that control direction of movements, resulting ill uni-directional circling or one-way gating between two areas. Furthermore, cells loaded with streptavidin beads following biotinylation of surface proteins moved at normal speeds. These bacteria could be useful as living microtransporters. carrying cargo around within micrometer-scale spaces. (c) 2005 Elsevier Inc. All rights reserved.