Emerging role of IGF-1R in stretch-induced neointimal hyperplasia in venous grafts.
Emerging role of IGF-1R in stretch-induced neointimal hyperplasia in venous grafts.
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DOI：
10.1161/atvbaha.107.148189
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发表时间：
2007-08
期刊：
影响因子：
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通讯作者：
Hannah Song;A. Mowbray;M. Sykes;H. Jo
中科院分区：
文献类型：
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作者：
Hannah Song;A. Mowbray;M. Sykes;H. Jo
自体大隐静脉通常用于在冠状动脉旁路移植术（CABG）过程中绕过闭塞的冠状动脉。1尽管这些血管为心肌缺血性疾病提供了有效的治疗方法，但它们易受加速动脉粥样硬化的影响，50%的病例在手术后10年内失败。2 -4静脉移植物疾病通过3种时间上不同的过程发生，包括血栓形成、新生内膜增生、和动脉粥样硬化，每一个过程都对下一个过程的发生起重要作用。在新生内膜增生期间，血管平滑肌细胞（VSMC）和细胞外基质在内膜区域积聚，导致内膜增厚和血管腔变窄。3 -5尽管已经描述了疾病过程，但细胞事件背后的详细机制尚不清楚。在这期《动脉炎、血栓形成和血管生物学》杂志中，Cheng和Du阐明了一种新的潜在机制，涉及胰岛素样生长因子（IGF-1）和IGF-1受体（IGF-1 R）通路，通过该通路，VSMC的周期性伸展在静脉移植物的内膜增厚中起着关键作用。参见第1744页血流产生广泛的血液动力学力，包括摩擦壁剪切应力、周向应力和压缩应力。6动脉暴露于可归因于脉动血流的循环周向拉伸。此外，它们比静脉承受更高的压力。而内皮细胞不断受到流体剪切应力，底层的平滑肌细胞主要暴露于圆周拉伸。它已被充分确立，改变机械力导致失调的细胞表型，并有助于疾病条件下的病理...
Autologous saphenous veins are commonly used to circumvent occluded coronary arteries during coronary artery bypass grafting (CABG) procedures.1 Although these vessels provide an effective treatment for myocardial ischemic disease, they are susceptible to accelerated atherosclerosis and fail in 50% of cases within 10 years of surgery.2–4 Venous graft disease occurs via 3 temporally distinct processes including thrombosis, neointimal hyperplasia, and atherosclerosis with each process contributing significantly to the onset of the next. During neointimal hyperplasia, vascular smooth muscle cells (VSMCs) and extracellular matrix accumulate in the intimal region causing intimal thickening and narrowing of the vessel lumen.3–5 Even though the disease process has been described, the detailed mechanisms behind the cellular events are unclear. In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology , Cheng and Du illustrate a novel underlying mechanism involving an insulin-like growth factor (IGF-1) and IGF-1 receptor (IGF-1R) pathway by which cyclic stretch of VSMC plays a critical role in intimal thickening of venous grafts. See page 1744 Blood flow generates a wide range of hemodynamic forces including frictional wall shear stress, circumferential stress, and compressive stress.6 Arteries are exposed to cyclic circumferential stretch attributable to pulsatile blood flow. Furthermore, they experience higher pressures than veins. Whereas the endothelium is constantly subjected to fluid shear stress, the underlying layers of smooth muscle cells are exposed mainly to circumferential stretch. It has been well established that altered mechanical forces cause dysregulated cellular phenotypes and contribute to pathology in disease conditions …