CYTOLOGIC EVIDENCE FOR 3 HUMAN X-CHROMOSOMAL SEGMENTS ESCAPING INACTIVATION
CYTOLOGIC EVIDENCE FOR 3 HUMAN X-CHROMOSOMAL SEGMENTS ESCAPING INACTIVATION
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DOI：
10.1007/bf00291539
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发表时间：
1983-01-01
期刊：
影响因子：
5.3
通讯作者：
MEER, B
中科院分区：
文献类型：
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作者：
SCHEMPP, W;MEER, B
用溴脱氧尿嘧啶核苷(BrdU)复制技术研究了代谢期前人类性染色体的早期复制。XP的两个末端片段，包括条带XP22.13和XP22.3，在S期早期复制，因此可能不会受到随机失活的影响。XP的这些远端片段的复制与Y染色体短臂的复制同步进行，包括YP11.2和YP11.32带。XP和Yp的这些片段很好地对应于X和Y染色体的配对片段，在那里人类精子发生的早期粗线期形成联会复合体。Yp和XP远端的同源早期复制可能是异形性染色体从原来的同态常染色体分化而未被触及的残留物。第三个早期复制片段位于X染色体的长臂上，与XQ 13.1带相关。该片段可能与Therman等人推测的X-失活中心相关。
Early replication of prometaphasic human sex chromosomes was studied with the bromodeoxyuridine (BrdU)-replication technique. Two distal segments of Xp, including bands Xp 22.13 and Xp 22.3, replicate early in S-phase and therefore may not be subject to random inactivation. The replication of these distal segments of Xp occurs synchronously with those of the short arm of the Y chromosome including bands Yp 11.2 and Yp 11.32. These segments of Xp and Yp correspond well to the pairing segment of the X and Y chromosomes where a synaptonemal complex forms at early pachytene of human spermatogenesis. The homologous early replication of Yp and the distal portion of Xp may be interpreted as a remnant left untouched by the differentiation of heteromorphic sex chromosomes from originally homomorphic autosomes. A 3rd early replicating segment is situated on the long arm of the X chromosome and corresonds to band Xq 13.1. This segment may be correlated with the X-inactivation center postulated by Therman et al.