Poverty, hunger, education, and residential status impact survival in HIV.

Poverty, hunger, education, and residential status impact survival in HIV.
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DOI:
10.1007/s10461-010-9759-z
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发表时间:
2011-10
期刊:
影响因子:
4.4
通讯作者:
Knox, Tamsin
Knox, Tamsin
中科院分区:
医学2区
文献类型:
--
作者:
McMahon, James;Wanke, Christine;Terrin, Norma;Skinner, Sally;Knox, Tamsin

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尽管联合抗逆转录病毒疗法(ART),艾滋病毒感染者的死亡率高于非感染者。较低的社会经济地位(SES)预测许多慢性疾病的死亡率较高,但艾滋病毒感染者的数据有限。我们评估了1995年至2005年878例HIV感染者。根据SES指标和其他因素估计全因死亡率的考克斯比例风险。混合效应分析研究了SES如何影响预测死亡的因素。死亡的200人年龄较大,CD 4计数较低,病毒载量较高。在单变量分析中,年龄、传播类别、教育、白蛋白、CD 4计数、VL、饥饿和贫困预测死亡;在多变量模型中,年龄、CD 4计数、白蛋白、VL和贫困预测死亡。混合模型显示(1)CD 4计数与教育和饥饿之间的关联;(2)白蛋白与教育,无家可归和贫困之间的关联;(3)VL与教育和饥饿之间的关联。社会经济地位直接或间接地导致艾滋病毒感染者的死亡,应成为这一人群的卫生政策目标。
Despite combination antiretroviral therapy (ART), HIV infected people have higher mortality than non-infected. Lower socioeconomic status (SES) predicts higher mortality in many chronic illnesses but data in people with HIV is limited. We evaluated 878 HIV infected individuals followed from 1995 to 2005. Cox proportional hazards for all-cause mortality were estimated for SES measures and other factors. Mixed effects analyses examined how SES impacts factors predicting death. The 200 who died were older, had lower CD4 counts, and higher viral loads (VL). Age, transmission category, education, albumin, CD4 counts, VL, hunger, and poverty predicted death in univariate analyses; age, CD4 counts, albumin, VL, and poverty in the multivariable model. Mixed models showed associations between (1) CD4 counts with education and hunger; (2) albumin with education, homelessness, and poverty; and (3) VL with education and hunger. SES contributes to mortality in HIV infected persons directly and indirectly, and should be a target of health policy in this population.
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