Activational role of cannabinoids on movement.
Activational role of cannabinoids on movement.
复制标题
大麻素对运动的激活作用。
DOI：
10.1016/s0014-2999(00)00044-3
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发表时间：
2000
影响因子：
5
通讯作者：
Walker,JM
中科院分区：
文献类型：
--
作者：
Sañudo-Peña,MC;Romero,J;Seale,GE;Fernandez-Ruiz,JJ;Walker,JM
大麻素对运动的主要影响是活动减退。然而，大麻素对运动的双相兴奋/抑制作用已被反复承认。然而，文献缺乏对这种效应的详细描述。在这项研究中，我们对Δ9-四氢大麻酚对运动的影响进行了剂量反应研究。在给予媒介物或一定剂量的Δ9-四氢大麻酚（0.2、0.5、1、1.5、2、2.5、3、4或5 mg/kg）后，立即将动物置于活动监测器中并观察1小时。记录了几个参数。水平和垂直活动被测量为活动监视器壁上的光电管之间断开的光束的数量。还记录了湿狗抖动、后爪抓挠、嘴部运动、前爪抖动的次数，以及每个受试者花费梳理的时间量（分钟）。记录粪便团的数量作为自主活动的指数。随后在棒试验中检测每只动物的僵住症。观察到三相效应：低剂量的大麻素受体激动剂Δ9-四氢大麻酚（0.2 mg/kg）降低自发活动，而较高剂量（1-2 mg/kg）剂量依赖性地刺激运动，直到出现僵硬症（2.5 mg/kg），伴随活动减少。
Cannabinoid's major effect on movement is hypoactivity. Nevertheless, a biphasic excitatory/inhibitory effect of cannabinoids on movement has been repeatedly acknowledged. However, the literature is lacking a detailed description of such an effect. In this study, we performed a dose–response study of the effects of Δ9-tetrahydrocannabinol on movement. Immediately after the administration of vehicle or a dose of Δ9-tetrahydrocannabinol (0.2, 0.5, 1, 1.5, 2, 2.5, 3, 4, or 5 mg/kg), the animal was placed in an activity monitor and observed for 1 h. Several parameters were recorded. The horizontal and vertical activities were measured as the number of photobeams broken between the photocells on the walls of an activity monitor. The number of wet dog shakes, scratches with hindpaw, mouth movements, forepaw flutters were also recorded, as was the amount of time in minutes that each subject spent grooming. The number of fecal boluses was recorded as an index of autonomic activity. Each animal was subsequently tested for catalepsy in the bar test. A triphasic effect was observed: low doses of the cannabinoid receptor agonist Δ9-tetrahydrocannabinol (0.2 mg/kg) decreased locomotor activity while higher doses (1–2 mg/kg) dose-dependently stimulated movement until catalepsy emerged (2.5 mg/kg) accompanied by decreases in activity.