Columbamides D and E: Chlorinated Fatty Acid Amides from the Marine Cyanobacterium Moorea bouillonii Collected in Malaysia
Columbamides D and E: Chlorinated Fatty Acid Amides from the Marine Cyanobacterium Moorea bouillonii Collected in Malaysia
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DOI：
10.1021/acs.orglett.7b01869
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发表时间：
2017-08-18
期刊：
影响因子：
5.2
通讯作者：
Okino, Tatsufumi
中科院分区：
文献类型：
--
作者：
Lopez, Julius Adam V.;Petitbois, Julie G.;Okino, Tatsufumi
从马来西亚沙巴州的布氏莫雷鸟样品的有机提取物中分离出两种新的氯化脂肪酸酰胺，即氨酰氨D（1）和E（2），以及apratoxins A和C和wewakazole。通过MS和NMR分析的组合完成结构解析。完成了化合物1的四个立体异构体的全合成，并通过手性HPLC和Marvet分析确定了其绝对构型。
Two new chlorinated fatty acid amides, columbamides D (1) and E (2), along with apratoxins A and C and wewakazole, were isolated from the organic extract of a Moorea bouillonii sample from Sabah, Malaysia. Structure elucidation was accomplished by a combination of MS and NMR analyses. The total synthesis of all four stereoisomers of 1 was completed, and the absolute configuration was determined by chiral-phase HPLC and Marfey's analysis.