Prenatal vitamin intake during pregnancy and offspring obesity
Prenatal vitamin intake during pregnancy and offspring obesity
复制标题
DOI：
10.1038/ijo.2014.107
复制
发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Michels, K. B.
中科院分区：
文献类型：
--
作者：
Dougan, M. M.;Willett, W. C.;Michels, K. B.
背景/目的：在动物研究中，接触多种维生素可能与后代肥胖有关；然而，在人类中的数据很少。因此，我们研究了孕期维生素摄入量与子女肥胖的关系。目的/方法：我们在护士健康研究II中调查了29160对母女的产前维生素摄入量与肥胖的关系。参与者的母亲与哺乳女儿一起提供了孕期维生素使用的信息。关于5岁和10岁时的身体肥胖、18岁时的身体质量指数(BMI)、1989年和2009年的体重、腰围和身高的信息都是从女儿那里获得的。多分类Logistic回归用于预测成年早期和成年期的BMI，以及儿童时期的体脂。用线性回归预测成年后的腰围。结果：无论是在儿童期还是成年期，在宫内暴露于维生素与体脂无关。孕期服用维生素的孕妇与未服用维生素的孕妇相比，其成年后肥胖的协变量调整优势比(OR)为0.99(95%可信区间为0.92~1.05，P值=0.68)。母亲孕期服用维生素的孕妇在5岁时体型最大的协方差OR为1.02(95%CI为0.90~1.15，P值=0.78)。在其他分析中，在宫内接触维生素也与成人腹部肥胖无关。结论：无论是在儿童时期还是成年后，孕期维生素暴露都与身体肥胖无关。
BACKGROUND/OBJECTIVES: In animal studies, exposure to multivitamins may be associated with obesity in the offspring; however, data in humans are sparse. We therefore examined the association between prenatal vitamin intake during pregnancy and offspring obesity.SUBJECTS/METHODS: We investigated the association between prenatal vitamin intake and obesity among 29 160 mother-daughter dyads in the Nurses' Health Study II. Mothers of participants provided information on prenatal vitamin use during pregnancy with the nurse daughter. Information on body fatness at ages 5 and 10, body mass index (BMI) at age 18, weight in 1989 and 2009, waist circumference, and height was obtained from the daughter. Polytomous logistic regression was used to predict BMI in early adulthood and adulthood, and body fatness in childhood. Linear regression was used to predict waist circumference in adulthood.RESULTS: In utero exposure to prenatal vitamins was not associated with body fatness, either in childhood or in adulthood. Women whose mothers took prenatal vitamins during pregnancy had a covariate-adjusted odds ratio (OR) of being obese in adulthood of 0.99 (95% confidence interval (CI) 0.92-1.05, P-value = 0.68) compared with women whose mothers did not take prenatal vitamins. Women whose mothers took prenatal vitamins during pregnancy had a covariate-adjusted OR of having the largest body shape at age 5 of 1.02 (95% CI 0.90-1.15, P-value = 0.78). In additional analyses, in utero exposure to prenatal vitamins was also unrelated to adult abdominal adiposity.CONCLUSIONS: Exposure to prenatal vitamins was not associated with body fatness either in childhood or in adulthood.