HEMATOCRIT AND RISK OF CORONARY HEART-DISEASE - THE PUERTO-RICO HEART HEALTH-PROGRAM
HEMATOCRIT AND RISK OF CORONARY HEART-DISEASE - THE PUERTO-RICO HEART HEALTH-PROGRAM
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DOI：
10.1016/0002-8703(81)90136-8
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发表时间：
1981-01-01
影响因子：
4.8
通讯作者：
HAVLIK, RJ
中科院分区：
文献类型：
--
作者：
SORLIE, PD;GARCIAPALMIERI, MR;HAVLIK, RJ
在参加波多黎各心脏健康计划的2555名农村和6161名城市男性中测定了红细胞压积[HcF]，该计划是一项冠状动脉疾病（CAD）的前瞻性流行病学研究。波多黎各心脏健康计划，冠状动脉疾病（CAD）的前瞻性流行病学研究。这些受试者接受了3次额外检查。通过8年的随访，详细记录了死因死亡率和冠心病（CHD）发病率。由于Hct是血液粘度的间接测量，因此评估了其作为CHD独立危险因素的价值。在波多黎各队列中，Hct在老年组中略低，农村地区略低于城市地区。在农村地区，4.6%的人Hct值低于40%;在城市地区，3.0%的人低于40%。高血细胞比容水平与吸烟、高相对血压和高血清胆固醇有关。在城市地区，Hct水平升高与心肌梗死（MI）、冠状动脉功能不全或CHD死亡的风险增加相关。高红细胞压积组（Hct > 49%）MI、冠状动脉功能不全或CHD死亡的发生率是低红细胞压积组（Hct < 42%）的两倍多。使用多变量logistic函数，调整上述风险因素后，该关系仍具有统计学显著性。Hct升高作为导致CHD死亡率和发病率的独立危险因素的潜在影响的问题被认为是。
Hematocrit [HcF] was determined in 2555 rural and 6161 urban men age 45-64 yr participating in the Puerto Rico Heart Healthy Program, a prospective epidemiologic study of coronary artery disease (CAD). Puerto Rico Heart Health Program, a prospective epidemiologic study of coronary artery disease (CAD). These participants were examined 3 additional times. Mortality by cause and coronary heart disease (CHD) morbidity were carefully documented for 8 yr of follow-up. Since Hct is an indirect measure of blood viscosity, its value as an independent risk factor of CHD was evaluated. Within the Puerto Rican cohort, Hct is slightly lower in older age groups and appears slightly lower in the rural than in the urban area. In the rural area 4.6% had Hct values below 40%; in the urban area 3.0% were below 40%. A higher Hct level was associated with cigarette smoking, higher relative higher blood pressure and higher serum cholesterol. An elevated Hct level was associated with an increased risk of myocardial infarction (MI), coronary insufficiency or CHD death in the urban area. Incidence of MI, coronary insufficiency or CHD death was more than double in the high hematocrit group (Hct > 49%) compared to the low group (Hct < 42%). Using a multivariate logistic function, the relationship remained statistically significant after adjustment for the above mentioned risk factors. The issue of the potential impact of elevated Hct as an independent risk factor contributing to the incidence of CHD mortality and morbidity is considered.